| HRA003461
(Controlled Access)
|
we report our pilot CCGA results which we comprehensively characterize the chromosomal DNA, extrachromosomal circular DNA, and transcriptomic alteration landscape in urothelial bladder carcinoma (UBC) of 80 patients by whole-genome/exon sequencing, Circle-seq, single-molecule long-read sequencing technology, and RNA sequencing. Leveraging these large amounts of pair-wise (UBC vs. normal adjacent tissue) and trans-OMICS (genome, circulome, transcriptome) data, we exploit the genome-wide landscape of circular DNA-associated somatic mutations, unbalanced structural variations, oncogene amplification, genomic distributions, structure, and correlations with altered gene expression and clinical outcomes in UBCs. |
