样本编号 SAMC3044325
外部数据库编号 GSA-Human: HRS932678
样品名称 N2
样本标题 N2
样品类型 Human sample
物种名称 Homo sapiens
描述信息 Adjacent normal sample 2
样本属性 *由于样本关联的数据集HRA005411尚未在科技部完成人类遗传资源信息备案,本页面只展示部分样本信息。
发布日期 2023-09-04
项目编号 PRJCA019049
提交者 shao  yebo  (shao.yebo@zsxmhospital.com)
提交单位 Zhongshan Hospital (Xiamen), Fudan University
提交日期 2023-09-05

样本包含数据信息

资源名称 描述
GSA-Human (1) -
HRA005411  (Open Access) Imatinib is the preferred targeted therapy for treating gastrointestinal stromal tumor (GIST), but resistance often occurs during treatment, thus limiting its efficacy and clinical application. We performed high-throughput sequencing of tissue specimens from imatinib-resistant GIST patients, screened for polymeric immunoglobulin receptor (PIGR), and identified significantly high expression of PIGR in imatinib-resistant cell lines. We further found that PIGR could specifically bind to LINC00870 and TMEM237, and overexpression of LINC00870 in GIST significantly inhibited the glycosylation modification and secretion of the extracellular region of PIGR, causing immune dysregulation. In this study, after screening PIGR by high-throughput sequencing, we further explored the critical molecules of PIGR in regulating GIST imatinib resistance, and elucidated the mechanism of PIGR in GIST imatinib treatment resistance, to provide a new theoretical basis for blocking drug resistance and improving prognosis.
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