样本编号	SAMC3277089
外部数据库编号	GSA-Human: HRS1016852
样品名称	HLA-B27-negative-2
样本标题	Peripheral blood mononuclear cells were obtained from hla-b27 negative JIA patients
样品类型	Human sample
物种名称	Homo sapiens
描述信息	Peripheral blood of hla-b27 negative JIA patients
样本属性	*该样本包含更多受控访问信息，请通过GSA-Human系统申请项目HRA006261数据获取。
发布日期	2023-12-22
项目编号	PRJCA022036
提交者	Yifei Li (liyfwcsh@scu.edu.cn)
提交单位	West China Second University Hospital, Sichuan University
提交日期	2023-12-23

样本包含数据信息

资源名称	描述
GSA-Human (1)	-
HRA006261 (Controlled Access)	Our study provided evidence of cellular and molecular levels of involvement in JIA pathogenesis and identified the critical roles for T cells in JIA pathogenesis. Furthermore, our results suggested that there were significant differences in T cell composition and gene expression between HLA-B27+ JIA patients and HLA-B27- JIA patients, which may contribute to the phenotypic differences between HLA-B27-positive and HLA-B27-negative JIA subtypes. Our findings indicated that CCR7+/RELB+/IRF1+ triple positive T cells could damage the cartilage of HLA-B27+ JIA by producing cytokines such as IL-17. Taken together, we believe that CCR7+/RELB+/IRF1+ triple positive T cells capable of producing large amounts of cytokines have the potential to serve as prognostic biomarkers in HLA-B27+ JIA patients.

资源名称

描述

GSA-Human (1)

HRA006261 (Controlled Access)

Our study provided evidence of cellular and molecular levels of involvement in JIA pathogenesis and identified the critical roles for T cells in JIA pathogenesis. Furthermore, our results suggested that there were significant differences in T cell composition and gene expression between HLA-B27+ JIA patients and HLA-B27- JIA patients, which may contribute to the phenotypic differences between HLA-B27-positive and HLA-B27-negative JIA subtypes. Our findings indicated that CCR7+/RELB+/IRF1+ triple positive T cells could damage the cartilage of HLA-B27+ JIA by producing cytokines such as IL-17. Taken together, we believe that CCR7+/RELB+/IRF1+ triple positive T cells capable of producing large amounts of cytokines have the potential to serve as prognostic biomarkers in HLA-B27+ JIA patients.