样本编号 SAMC3447555
外部数据库编号 GSA-Human: HRS1186585
样品名称 231-PLKO
样本标题 231-PLKO
样品类型 Human sample
物种名称 Homo sapiens
描述信息 Stable cell line
样本属性
分离株名称 not collected
年龄
实验材料提供者 Yu'lab
性别 female
组织器官 MDA-MB-231 cell
疾病名称
细胞系
细胞亚型
细胞类型
收集/保存方法
发育阶段
疾病分期
血统性(民族)
健康状况
核型
表型
人口
种族(人种)
类型
处理方法
用户自定义属性
发布日期 2024-03-17
项目编号 PRJCA024162
提交者 xian  zhao  (jianxiu.yu@gmail.com)
提交单位 Shanghai Jiao Tong University School of Medicine
提交日期 2024-03-18

样本包含数据信息

资源名称 描述
GSA-Human (1) -
HRA006882  (Open Access) Endoribonuclease DICER is an RNase III enzyme that mainly processes microRNAs in the cytoplasm but also participates in nuclear functions such as chromatin remodelling, epigenetic modification and DNA damage repair. The expression of nuclear DICER is low in most human cancers, suggesting a tight regulation mechanism that is not well understood. Here, we found that ubiquitin carboxyl-terminal hydrolase7 (USP7), a deubiquitinase, bounded to DICER and reduced its nuclear protein level by promoting its ubiquitination and degradation through MDM2, a newly identified E3 ubiquitin-protein ligase for DICER. This USP7-MDM2-DICER axis impaired histone H2AX signalling and the recruitment of DNA damage response (DDR) factors, possibly by influencing the processing of small DDR noncoding RNAs. We also showed that this negative regulation of DICER by USP7 via MDM2 was relevant to human tumours using cellular and clinical data.
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