| GVM000712 | ZJCRC case-control set: Participants were recruited from a one-to-one matched case-control study conducted from 2015 to 2022 based on an ongoing population-based CRC screening program running in Jiashan County, Zhejiang Province, China. The recruitment and diagnostic criteria and inclusion and exclusion criteria were previously reported. Demographic and lifestyle information was collected from questionnaires survey or direct measurement including age, sex, family history of CRC and lifestyle habits. Written informed consent was obtained from all the study subjects. The disease stage classification was in accordance with the World Health Organization (WHO) classification standard. Each participant had undergone a high-quality colonoscopy examination. A total of 1,814 patients with advanced colorectal neoplasm (including 1,622 advanced adenoma and 192 cancer cases) and 1,814 lesion-free controls were finally included in this study.
ZJCRC cross-sectional screening set: Participants were recruited from a cross-sectional screening study performed in 2014, as a part of the early work on the CRC screening program conducted in Jiashan County. More information about the data collection process is available in our previous report. Written informed consent was obtained from all the study subjects. 123 patients with advanced colorectal neoplasm (including 108 advanced adenoma and 15 cancer cases), 549 patients with non-advanced adenoma, and 1,672 normal individuals without finding by colonoscopy were included. |
