| HRA007683
(Controlled Access)
|
Maternal effect factors play an important role in the regulation of human egg maturation and early embryo development. In recent years, clinical studies have reported many maternal effect gene mutations closely related to female infertility. This project is aimed at patients with egg and embryo development disorders. The maternal effector factor protein expression, DNA methylation, and metabolism levels are detected and compared. By combining the prediction of complex stability of maternal effector factors and the in vitro reconstitution, this project will provide methods for identifying pathogenic variants, reveal the pathogenesis of maternal effect factors related-infertility, and explore the possible clinical diagnostic and treatment strategies. |
