样本编号	SAMC6561315
外部数据库编号	GSA-Human: HRS2101850
样品名称	Proteosome_S2C
样本标题	S2C_DMSO
样品类型	Human sample
物种名称	Homo sapiens
描述信息	Human T cells were isolated from peripheral blood mononuclear cells (PBMCs) of healthy donors, activated with CD3/CD28 beads, and then transduced with a CD19 CAR construct. Five days later, the CAR T cells were treated with DMSO for 48 hours. The CAR T cells were then washed and co-cultured with Nalm6 cells at a 1:1 ratio for an additional 48 hours. Subsequently, CD19 CAR live cells were sorted and subjected to single-cell RNA sequencing (scRNA-seq).
样本属性	*该样本包含更多受控访问信息，请通过GSA-Human系统申请项目HRA014168数据获取。
发布日期	2026-01-25
项目编号	PRJCA048991
提交者	Yingxi Xu (xuyingxi@ihcams.ac.cn)
提交单位	Peking Union Medical College
提交日期	2026-01-09

样本包含数据信息

资源名称	描述
GSA-Human (1)	-
HRA014168 (Controlled Access)	Our previous data showed that CAR T cells with high proteasome activity exhibit reduced therapeutic efficacy due to their tendency to undergo terminal differentiation. And pre-treatment of CAR T cells during manufacturing with a low dose of bortezomib significantly improved their anti-tumor efficacy. To investigate how short-term bortezomib treatment prolongs the survival of leukemia-bearing mice, we performed single-cell multi-omics (scMulti-omics) analysis.

资源名称

描述

GSA-Human (1)

HRA014168 (Controlled Access)

Our previous data showed that CAR T cells with high proteasome activity exhibit reduced therapeutic efficacy due to their tendency to undergo terminal differentiation. And pre-treatment of CAR T cells during manufacturing with a low dose of bortezomib significantly improved their anti-tumor efficacy. To investigate how short-term bortezomib treatment prolongs the survival of leukemia-bearing mice, we performed single-cell multi-omics (scMulti-omics) analysis.