| HRA014233
(Controlled Access)
|
Polybrominated diphenyl ethers (PBDEs) are implicated in dyslipidemia, but the molecular basis of individual susceptibility remains elusive. By integrating exposome, genomics, and metabolomic data in the China National Human Biomonitoring cohort, we identified 3,571 genetic variants that interact with PBDE exposure to influence dyslipidemia risk. Metabolomic analysis highlighted glycine and glycerophosphate as key mediators. A polygenic risk score derived from these PBDE-interactive variants significantly enhanced dyslipidemia prediction in highly exposed individuals. |
