Agonist stimulation induces an anisotropic response with conformational changes of CXCR3-A along its longitudinal axis CXCR3-A is internalized via clathrin-coated vesicles and recycled by retrograde trafficking We demonstrate that CXCR3-A interacts with LRP1 Silencing of LRP1 inhibits CXCR3 internalization with an increase in the magnitude of ligand-induced conformational change with CXCR3-A focalized at the cell membrane, leading to a sustained receptor activity and an increase in tumor cell migration.
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