BrainBase a curated knowledgebase for brain diseases

Summary

Gene Symbol:	METEX14
Alias:	_
External Link:	GeneCards

Diseases

Drugs

Specific Gene

Brain Specific Gene	Brain-Region Specific Gene	Brain Specific Protein	Cerebrospinal Fluid Protein	Cell Marker

Brain Specific Gene	Brain-Region Specific Gene	Brain Specific Protein	Cerebrospinal Fluid Protein	Cell Marker
-	-	-	-	-

Omics Signature (Glioma)

Molecular Role

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Type	Omics	Alteration	Detail	Pathway	Tumor Process	Description	PMID
mRNA	Genomics	mutation	exon 14 skipping on MET transcript	MET/STAT3	proliferation	Hyper-activation of MET/STAT3 signaling pathway and elevated proliferation and angiogenesis activities while progressing into the METex14-positive sGBM.	30343896

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Regulation axis

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Experimental Sample

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Disease	Subtype	Grade	Species	Tissue / Cell Line	Description	PMID
Glioblastoma	secondary glioblastoma	G4	Rattus norvegicus; Homo Sapiens	U87 MG; N33	Clonal and subclonal METex14 promote glioma progression and mark worse prognosis.	30343896

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