gene number KMT2D 11 TP53 11 KMT2C 10 NOTCH1 9 SPEN 9 KEAP1 7 PIK3CA 7 FAT1 6 APC 5 FBXW7 5 STK11 5 ATM 4 ATR 4 EP300 4 FLT4 4 NOTCH3 4 PTEN 4 SMARCA4 4 AKT1 3 BRCA2 3 CASP8 3 CDKN2A 3 CREBBP 3 EGFR 3 ERBB2 3 ERBB4 3 FLT1 3 GNAS 3 KMT2A 3 KRAS 3 ROS1 3 RUNX1 3 ARID1A 2 BRAF 2 BRIP1 2 CDH1 2 CDK4 2 CHEK2 2 CSF3R 2 CTNNB1 2 EPHA3 2 ERCC4 2 GRIN2A 2 JUN 2 KDM5C 2 KDM6A 2 KDR 2 MAP3K1 2 NF1 2 NFE2L2 2 NSD1 2 RAD54L 2 RET 2 RNF43 2 RYR2 2 SMAD3 2 SMAD4 2 TBC1D20 2 TERT 2 ADHFE1 1 AKT3 1 ALK 1 AMER1 1 AMPH 1 AR 1 ATRX 1 AURKA 1 AXIN1 1 AXL 1 B2M 1 BAP1 1 BCL2 1 BCOR 1 BLM 1 BRCA1 1 BRD9 1 CA9 1 CBFB 1 CCNE1 1 CD1D 1 CD274 1 CD28 1 CD55 1 CD74 1 CD79B 1 CDC73 1 CDKN2C 1 CEBPA 1 COL11A1 1 COL1A1 1 CRTC1 1 CSF1R 1 CYLD 1 DDR2 1 DIAPH1 1 DICER1 1 DNMT3A 1 DOT1L 1 DPYD 1 E2F1 1 EPCAM 1 EPHA2 1 EPHA7 1 EPHX1 1 ERBB3 1 ERC1 1 ETV1 1 ETV6 1 EZH2 1 FGFR2 1 FGFR3 1 FLT3 1 FOXL2 1 FUBP1 1 GNA11 1 GRIK1 1 HGF 1 HOXB13 1 HRAS 1 IKBKE 1 IKZF1 1 IL7R 1 IRF4 1 IRS2 1 ITGAX 1 JAK1 1 KIT 1 KMT2B 1 MAPK1 1 MEF2B 1 MET 1 MLH1 1 MTHFR 1 MTOR 1 MYH9 1 NFKBIA 1 NLRP3 1 NPM1 1 NTRK1 1 NTRK2 1 NUP93 1 PAX5 1 PDGFRA 1 PDP2 1 PFKL 1 PIK3C3 1 PIK3CB 1 PIK3CG 1 PIK3R1 1 PIK3R2 1 POLD1 1 POLE 1 RASAL1 1 RB1 1 RPTOR 1 SDC4 1 SELL 1 SF3B1 1 SMO 1 SRC 1 SRCAP 1 SRGAP3 1 SRXN1 1 SUZ12 1 SYK 1 TET2 1 TGFBR2 1 THRB 1 TOP1 1 TOP2A 1 TSC1 1 TSC2 1 UBE2D2 1 WHSC1 1 XPC 1 XPO1 1 ZFHX3 1 ZNF276 1