gene number TP53 102 NOTCH1 26 FAT1 13 EP300 11 FBXW7 11 KMT2C 9 PTCH1 9 NOTCH2 8 RB1 8 NFE2L2 7 NOTCH3 7 KEAP1 6 KMT2A 6 KMT2D 6 BAP1 5 CDKN2A 5 CREBBP 5 DNMT3A 5 MTOR 5 ATM 4 CSMD3 4 NTRK2 4 PIK3CG 4 PTEN 4 SMAD4 4 TSC2 4 WHSC1L1 4 ALK 3 ARID1A 3 ASXL1 3 ATR 3 BRCA2 3 ERBB2 3 ERBB4 3 GLI1 3 KDR 3 KRAS 3 MSH3 3 POLD1 3 POLE 3 RUNX1T1 3 TET2 3 APC 2 ARFRP1 2 AXL 2 BCOR 2 BRAF 2 BRCA1 2 CARD11 2 CASP8 2 DICER1 2 DPYD 2 EGFR 2 EML4 2 EPHA3 2 EPHA5 2 ESR1 2 FGF3 2 HGF 2 IKBKE 2 IRF4 2 JAK2 2 KDM5A 2 KDM6A 2 KIT 2 LYN 2 MAP3K1 2 MED12 2 MPL 2 NBN 2 NF1 2 NLRP3 2 NTRK3 2 PDGFRB 2 PIK3C2G 2 PIK3CA 2 PRDM1 2 RBM10 2 RET 2 RICTOR 2 RYR2 2 SETBP1 2 SETD2 2 SMAD3 2 SPEN 2 TGFBR2 2 TRPS1 2 XPO1 2 ABL1 1 ACP5 1 ACSM2A 1 ADGRA2 1 AFF1 1 AKT1 1 AMER1 1 AMPH 1 APOB 1 AR 1 ARAF 1 ARID2 1 ASPM 1 ATIC 1 AURKA 1 AXIN1 1 B2M 1 BAK1 1 BCL2L11 1 BRINP3 1 BRIP1 1 BTG2 1 BTK 1 CADM1 1 CAMK1 1 CANT1 1 CCND2 1 CD274 1 CD68 1 CDC73 1 CDKN1A 1 CHEK2 1 CIC 1 CLIP1 1 COL1A2 1 CSF1R 1 CST6 1 CTNNB1 1 CUL3 1 CXCR4 1 CYLD 1 CYP2B6 1 CYP2C19 1 CYP2E1 1 DDR2 1 DIS3 1 EIF3A 1 EPHA4 1 EPHB1 1 ERBB3 1 ERC1 1 ERCC1 1 ERCC4 1 ETV1 1 EWSR1 1 FAM131B 1 FAM135B 1 FANCA 1 FANCC 1 FAT4 1 FBXO11 1 FEV 1 FH 1 FLCN 1 FLT3 1 FOLR2 1 FOXP1 1 FUBP1 1 GAPDHS 1 GGCT 1 GNAQ 1 HIST1H3B 1 HIST1H3D 1 HIST1H3E 1 HIST1H3H 1 HIST1H4A 1 HN1 1 IDH1 1 IGF1R 1 ITCH 1 JAK3 1 JUN 1 KDM5C 1 KHDRBS2 1 KLF6 1 KLLN 1 LMO1 1 LRP1B 1 MACC1 1 MALT1 1 MKI67 1 MLH1 1 MSH2 1 MSH6 1 MTAP 1 MYCN 1 MYD88 1 NCAM2 1 NEK8 1 NKX2-1 1 NSD1 1 NT5C2 1 NTRK1 1 NUP93 1 OBSCN 1 PDCD1 1 PDGFB 1 PDGFRA 1 PDP1 1 PFKFB1 1 PFKFB2 1 PFKP 1 PHKG2 1 PIK3R1 1 PIK3R2 1 PLCG2 1 PLEKHH2 1 PLK1 1 PNMT 1 PPIF 1 PREX2 1 PRKCI 1 PTPN11 1 PTPRB 1 RAC1 1 RAD50 1 RAD51 1 RAD51D 1 RARA 1 RASGRF2 1 RNF43 1 ROS1 1 RUNX1 1 SDHA 1 SDHB 1 SGK1 1 SIGLEC7 1 SMAD2 1 SMARCA4 1 SNCAIP 1 SOD2 1 SOX2 1 SPOP 1 STAG2 1 STX5 1 SULT2B1 1 SUZ12 1 SYNE1 1 TBX3 1 TFG 1 TGM2 1 TLR4 1 TMEM99 1 TMPRSS2 1 TOP1 1 TPBG 1 TSC1 1 TTF1 1 VEGFA 1 WHSC1 1 WT1 1 YAP1 1 ZC3H13 1 ZFHX4 1