gene number TP53 15 KEAP1 4 PTCH1 4 VHL 4 CREBBP 3 CTNNB1 3 DNMT3A 3 EP300 3 ERBB3 3 KMT2D 3 NFE2L2 3 SPEN 3 APC 2 ARID1A 2 BRCA1 2 BRIP1 2 CARD11 2 FH 2 FUBP1 2 GNAS 2 KDM5C 2 KDM6A 2 KMT2A 2 KMT2C 2 NF1 2 NTRK3 2 PIK3CA 2 PIK3CG 2 PRKAR1A 2 PTEN 2 SETD2 2 SMARCA4 2 TGFBR2 2 ABL1 1 AKT1 1 ARID1B 1 ARNT 1 ARRDC3 1 ATM 1 ATRX 1 BCL2L1 1 BCOR 1 BRAF 1 BRCA2 1 BTG1 1 CASP8 1 CCNA1 1 CCND3 1 CD79B 1 CDH19 1 CDK12 1 CDK8 1 CDKN1A 1 CDKN2A 1 CIC 1 CLTC 1 CSDE1 1 CSF1R 1 CSF3R 1 CTCF 1 CXCR4 1 DICER1 1 EGFR 1 ELMO1 1 EPHA3 1 ERG 1 EZH2 1 FANCA 1 FBXW7 1 FGFR3 1 FLT1 1 FLT3 1 FLT4 1 FOXL2 1 GLI1 1 GNA13 1 HGF 1 HMGCR 1 HNF1A 1 HRAS 1 IDH1 1 IGF1R 1 INPP4B 1 IRS2 1 JAK3 1 KDM5A 1 KDR 1 MET 1 MITF 1 MLH1 1 MLLT10 1 MPL 1 MSH6 1 MTOR 1 MYC 1 NAV3 1 NBN 1 NOTCH3 1 NT5C1A 1 NUP93 1 OGDH 1 PARP1 1 PAX5 1 PBRM1 1 PDGFB 1 PIK3CB 1 POLE 1 PPP2R1A 1 PTPRG 1 PTTG1 1 RAD21 1 RAD52 1 RAD54L 1 RB1 1 ROS1 1 SF3B1 1 SMAD4 1 SPOP 1 STAG2 1 STAT3 1 SYNE2 1 TCN1 1 TNFAIP3 1 TSC1 1 TSC2 1