gene number TP53 533 EGFR 137 RB1 94 KEAP1 83 SMARCA4 73 RBM10 71 APC 70 KMT2D 66 STK11 58 ARID1A 56 FAT1 56 CDKN2A 50 ALK 46 ERBB4 45 NF1 45 NOTCH1 45 SMAD4 43 PIK3CA 42 BRCA2 40 ATM 39 MED12 38 BRCA1 37 PIK3CG 37 ARID2 36 ERBB2 36 SETD2 36 KMT2C 35 EP300 34 PREX2 34 EPHA5 33 NOTCH2 33 NTRK3 32 PIK3C2G 31 EPHA3 30 SPEN 30 ATRX 29 EPHB1 29 KMT2A 29 TET2 29 GNAS 27 GRIN2A 27 PBRM1 26 PDGFRA 26 RET 26 ATR 25 CARD11 25 MET 25 ARID1B 24 GLI1 24 NFE2L2 24 NOTCH3 23 BRAF 22 CTNNB1 22 INHBA 22 KIT 22 MTOR 22 POLE 22 RICTOR 22 CREBBP 21 DDR2 21 EPHA7 21 FBXW7 21 KDR 21 ROS1 21 DNMT3A 20 AMER1 19 BARD1 19 FLT4 19 IL7R 19 KRAS 18 PTEN 18 STAG2 18 FLT1 17 KDM5C 17 MSH6 17 NSD1 17 TGFBR2 17 HGF 16 PTCH1 16 ASXL1 15 BCOR 15 DOT1L 15 ESR1 15 FGFR2 15 GATA3 15 TSHR 15 WT1 15 DPYD 14 PIK3R1 14 PLCG2 14 AR 13 CASP8 13 CBL 13 CDC73 13 CDK12 13 ERBB3 13 ETV6 13 IGF1R 13 JAK3 13 KDM6A 13 RPTOR 13 TERT 13 BRIP1 12 DIS3 12 FGFR4 12 FLT3 12 FUBP1 12 IRF4 12 KDM5A 12 MAP2K1 12 NKX2-1 12 NTRK1 12 PARK2 12 PDGFRB 12 TSC1 12 TSC2 12 ABL1 11 ARAF 11 CEBPA 11 CSF1R 11 DICER1 11 ERRFI1 11 FOXP1 11 INPP4B 11 IRS2 11 MAP3K1 11 MEN1 11 NLRP3 11 PIK3CB 11 RAD50 11 WHSC1 11 BAP1 10 BLM 10 CDH1 10 CIC 10 FGFR3 10 MITF 10 MSH2 10 MSH3 10 PARP1 10 PIK3R2 10 POLD1 10 PPP2R1A 10 RNF43 10 SMAD3 10 SMO 10 AKT3 9 CTCF 9 FANCA 9 FGF4 9 FLCN 9 GNA13 9 MAP2K4 9 MYCN 9 NRAS 9 NTRK2 9 RYR2 9 SF3B1 9 SOX9 9 SPOP 9 TBX3 9 TNFAIP3 9 BTK 8 CUL3 8 IDH1 8 LRRC4C 8 MCL1 8 MLH1 8 NBN 8 NFKBIA 8 PALB2 8 RARA 8 RUNX1 8 SMAD2 8 ALOX12B 7 B2M 7 BRD4 7 CCND1 7 CDH19 7 CXCR4 7 ERCC4 7 ETV1 7 EZH2 7 FAT3 7 FGF19 7 FGF3 7 FGFR1 7 FH 7 GATA2 7 IKBKE 7 MRE11A 7 MYC 7 PEG3 7 PRDM1 7 SLC34A2 7 SMARCB1 7 WHSC1L1 7 AXIN1 6 AXL 6 CD79B 6 CHEK1 6 CSF3R 6 CYLD 6 DOCK2 6 FANCG 6 JAK2 6 LYN 6 MPL 6 NT5C2 6 RAD51B 6 SDHA 6 SLCO1B1 6 SOX2 6 SRC 6 ABCB1 5 AKT1 5 BRINP1 5 CCND2 5 EXT1 5 HNF1A 5 HRAS 5 JAK1 5 MAP3K4 5 MDM2 5 MDM4 5 MYD88 5 NUP93 5 PDCD1 5 RAD21 5 RAD54L 5 SPAG17 5 SYK 5 TOP1 5 AURKA 4 BCL2L1 4 CDK6 4 CDK8 4 CDKN1A 4 CHEK2 4 CYP2C9 4 ERG 4 FAM135B 4 FOXL2 4 GRIK1 4 GRM8 4 GSK3B 4 IGF2 4 JUN 4 LRP2 4 MKI67 4 MUTYH 4 PAK3 4 PAX5 4 PMS2 4 PRKAR1A 4 RAF1 4 RUNX1T1 4 SDHB 4 SETBP1 4 SLC5A8 4 SRGAP3 4 STAT3 4 TRIM33 4 VEGFA 4 ZFHX4 4 ABCG2 3 AKT2 3 ARNT 3 ASPM 3 ATP7B 3 BCR 3 CALR 3 CBFB 3 CBR1 3 CCNE1 3 CD79A 3 CDA 3 COL1A1 3 ELMO1 3 EPHA2 3 EPS15 3 FAM46C 3 FANCC 3 FAS 3 FES 3 FGF10 3 FLI1 3 GATA6 3 GLI3 3 GPC1 3 HERPUD1 3 HOXA13 3 JAG1 3 KLF6 3 MDH2 3 NAV3 3 NFASC 3 PDE10A 3 PDGFB 3 PKHD1 3 PLK1 3 PTPRD 3 PTPRT 3 RAD51D 3 SERPINA7 3 TGFBR3 3 TLR4 3 TNFRSF14 3 TRPS1 3 TRPV4 3 UGT1A1 3 VHL 3 XPO1 3 ZIC3 3 ZNF189 3 ZNF521 3 ABCA1 2 ABCB11 2 ABCC9 2 ACE 2 AFF4 2 AKAP9 2 ALB 2 ALDH2 2 ALOX12 2 APCS 2 APOB 2 ARHGAP9 2 ARID5B 2 ARRDC3 2 ATAD5 2 AXIN2 2 BAG1 2 BCL2 2 BCL6 2 CA1 2 CADM1 2 CARS 2 CBX5 2 CCNB1 2 CD1D 2 CD274 2 CD28 2 CD40LG 2 CD74 2 CDH8 2 CDK4 2 CDKN1B 2 CDKN2B 2 COL11A1 2 CPA4 2 CTSA 2 CXCL8 2 CYP2C19 2 CYP2D6 2 CYP2E1 2 CYP3A4 2 CYP46A1 2 DSE 2 DST 2 EPCAM 2 ETV5 2 EXT2 2 FASLG 2 FCN1 2 FOXA1 2 FOXO3 2 FPGS 2 GABRA6 2 GAK 2 GATA1 2 GDF7 2 GOLGA5 2 GRM3 2 GSS 2 GXYLT1 2 HEY1 2 HIST1H3D 2 HOOK3 2 IL1RL1 2 ING1 2 INSRR 2 IRS1 2 KAT6A 2 KIF5B 2 L2HGDH 2 MAP2K3 2 MEF2B 2 MMP11 2 MYCL 2 NCAM2 2 NR3C2 2 NRG1 2 PAPOLG 2 PCLO 2 PDE11A 2 PFKFB1 2 PFKM 2 PGK2 2 PHKG2 2 PI4KA 2 PLAT 2 PPM1D 2 PRKCI 2 PTPRB 2 PTPRK 2 RAD51 2 RAD51C 2 RAD52 2 RHOBTB2 2 RIPK2 2 RPS6KB1 2 RSPO1 2 SEPT9 2 SERPINB3 2 SFRP2 2 SIGLEC7 2 SLC9A9 2 SLCO1B3 2 SLIT2 2 SLX4 2 SMAD7 2 SOCS1 2 SPTA1 2 SRCAP 2 STS 2 SUCLG1 2 TBX5 2 TCF4 2 TCN1 2 TGFBR1 2 TMEM51 2 TOP2B 2 TP73 2 TPBG 2 TPMT 2 TTK 2 TTLL2 2 UGT1A6 2 XBP1 2 ZNRF3 2 ZRSR2 2 ABCC3 1 ACO2 1 ACPP 1 ACSM2A 1 ADAM22 1 ADSS 1 AFF1 1 AIP 1 ALDOA 1 ALS2CL 1 AMPH 1 APEX1 1 ARHGAP6 1 ATIC 1 ATP5S 1 BAX 1 BCORL1 1 BRD7 1 BRINP3 1 BTG1 1 BTRC 1 BUB1B 1 CAMK2A 1 CANT1 1 CASP2 1 CAST 1 CCDC178 1 CCNA1 1 CCND3 1 CCNE2 1 CD180 1 CD3EAP 1 CD55 1 CDKN1C 1 CDKN2C 1 CLIP1 1 CLTC 1 CNOT1 1 COL18A1 1 COL4A1 1 CPA1 1 CRHBP 1 CRKL 1 CSF2RB 1 CSNK1A1 1 CYP2C8 1 D2HGDH 1 DENND1A 1 DERL3 1 DLAT 1 DMD 1 DPEP1 1 DROSHA 1 DUSP2 1 DVL1 1 ECT2L 1 EML4 1 EPHA4 1 ERAP2 1 ERCC2 1 ERCC6 1 EREG 1 ETV4 1 EWSR1 1 FAM131B 1 FANCE 1 FANCL 1 FAP 1 FASN 1 FAT2 1 FAT4 1 FCRL1 1 FECH 1 FEV 1 FRS2 1 FTSJ2 1 G6PC 1 GABBR2 1 GALNT12 1 GLO1 1 GNA11 1 GPI 1 GSTM1 1 GSTP1 1 GUSB 1 HAL 1 HIF1A 1 HIST1H3B 1 HIST1H3C 1 HIST1H3F 1 HIST1H3G 1 HIST1H3H 1 HIST1H3I 1 HIST1H3J 1 HK1 1 HK2 1 HK3 1 HNRNPA2B1 1 HOXB13 1 HSD3B1 1 HSP90AA1 1 HSPA8 1 ID3 1 IDH2 1 IDH3A 1 IDH3G 1 IGSF10 1 IKZF1 1 IKZF3 1 IL2 1 IL20RA 1 IL6ST 1 ING2 1 INS-IGF2 1 IQGAP1 1 ITGA4 1 KLHL12 1 KMO 1 KMT2B 1 KRT8 1 KSR2 1 LANCL1 1 LATS1 1 LDHAL6A 1 LDHAL6B 1 LIFR 1 LIMD1 1 LIPF 1 LMO1 1 LRIG3 1 LRP1B 1 LRP6 1 LRRC34 1 LSM14A 1 LTA4H 1 LY86 1 LY96 1 MACC1 1 MAD1L1 1 MAGI2 1 MALT1 1 MAP4K3 1 MAPK11 1 MAX 1 MED19 1 METAP1 1 MFSD11 1 MIF 1 MLH3 1 MSN 1 MTAP 1 MTBP 1 MTHFR 1 NALCN 1 NAMPT 1 NAT2 1 NEDD4L 1 NEO1 1 NR4A3 1 NUDC 1 NUTM1 1 OGDH 1 PARP2 1 PDCD1LG2 1 PDE4B 1 PDGFA 1 PDIA2 1 PDK1 1 PDK4 1 PFKFB3 1 PFKL 1 PIK3C2B 1 PIK3C3 1 PKD2 1 PKLR 1 PLAU 1 PLXNC1 1 POLB 1 POLK 1 POT1 1 PPHLN1 1 PPIP5K2 1 PPP2R1B 1 PRDM2 1 PREP 1 PRKCB 1 PROKR2 1 PTPN1 1 PTPN11 1 PUS1 1 PYGM 1 QKI 1 RAC1 1 RALB 1 RARG 1 RASAL1 1 RASGRF2 1 RBP4 1 RECQL 1 RECQL4 1 RHOA 1 RPS6KC1 1 RRM1 1 RTEL1 1 SAMD9L 1 SCN10A 1 SDC4 1 SDHAF2 1 SELL 1 SEMA3C 1 SETD3 1 SGK1 1 SH2B3 1 SLC16A1 1 SLC16A8 1 SLC19A1 1 SLC28A2 1 SLIT1 1 SMARCA1 1 SNCAIP 1 SNRNP200 1 SOD2 1 SOS2 1 SRSF2 1 ST14 1 STAT1 1 STAT4 1 STMN1 1 SUCLG2 1 SUFU 1 SUZ12 1 SYNE1 1 SYNE2 1 TACC3 1 TBC1D20 1 TBC1D8B 1 TEK 1 TEKT4 1 TEX14 1 TFG 1 THADA 1 THRA 1 TMPRSS2 1 TNFRSF11A 1 TNFRSF19 1 TNFSF14 1 TPM4 1 TPP1 1 TSG101 1 TTLL5 1 TTR 1 UBE2D1 1 UBR3 1 UBR5 1 ULBP3 1 UMPS 1 UPP1 1 USP25 1 USP6 1 WAS 1 WEE1 1 WRN 1 WWP1 1 XDH 1 XRCC1 1 YAP1 1 ZADH2 1 ZBTB2 1 ZMIZ1 1 ZNF217 1 ZNF444 1