gene number TP53 229 KMT2D 51 NFE2L2 41 CDKN2A 39 FAT1 37 NOTCH1 37 RB1 29 KEAP1 28 FBXW7 26 KMT2C 23 PIK3CG 21 EP300 19 ERBB4 19 GRIN2A 19 PREX2 19 EGFR 17 ROS1 17 APC 16 BRCA2 16 ARID1A 15 ATM 15 EPHA3 15 ALK 14 FLT1 14 NF1 14 PIK3CA 14 PTEN 14 ATR 13 BCOR 12 DDR2 12 EPHA5 12 EPHB1 12 TSC2 12 CUL3 11 KDR 11 NSD1 11 SETD2 11 SMARCA4 11 ESR1 10 RICTOR 10 ASXL1 9 CYLD 9 FOXP1 9 GNAS 9 KRAS 9 NOTCH3 9 NTRK1 9 NTRK3 9 PDGFRA 9 POLE 9 STK11 9 TGFBR2 9 WHSC1 9 ATRX 8 CREBBP 8 IL7R 8 KDM6A 8 KIT 8 MET 8 MTOR 8 NTRK2 8 PIK3C2G 8 PRKCI 8 TSC1 8 BAP1 7 BRCA1 7 CIC 7 CXCR4 7 DICER1 7 EZH2 7 FLT4 7 KDM5C 7 RBM10 7 ARID1B 6 ARID2 6 BRIP1 6 CARD11 6 CSF1R 6 ERBB2 6 JAK3 6 NAV3 6 NBN 6 NFKBIA 6 PBRM1 6 PTCH1 6 SPEN 6 ZFHX4 6 CASP8 5 CBL 5 CTCF 5 CTNNB1 5 DOT1L 5 EPHA7 5 ERBB3 5 FGFR2 5 FGFR3 5 FLT3 5 GATA3 5 GLI1 5 HGF 5 IKZF1 5 IRS2 5 JAK2 5 KMT2A 5 MSH2 5 MSH6 5 NOTCH2 5 PAX5 5 PIK3R2 5 PLCG2 5 SMO 5 STAG2 5 ALB 4 AMER1 4 AR 4 ARAF 4 AXL 4 BARD1 4 BRAF 4 DNMT3A 4 FLCN 4 FOXL2 4 IGF1R 4 IGF2 4 JAK1 4 MAP3K1 4 MED12 4 NKX2-1 4 PARP1 4 PDGFRB 4 PIK3CB 4 PPP2R1A 4 RAF1 4 RET 4 RPTOR 4 SLX4 4 TBX3 4 TERT 4 TET2 4 WHSC1L1 4 ABCB1 3 ABCC9 3 ABL1 3 AKT2 3 AKT3 3 ALOX12B 3 BRINP3 3 BTK 3 CCNE1 3 CDH1 3 CEBPA 3 CSMD3 3 CTSS 3 CYP2C19 3 DIS3 3 DPYD 3 ERCC4 3 ETV1 3 ETV6 3 FAS 3 FGFR4 3 GATA2 3 IKBKE 3 INPP4B 3 IRF4 3 JUN 3 LMO1 3 LRP1B 3 MITF 3 MYC 3 NLRP3 3 PALB2 3 RAD21 3 RAD51C 3 RNF43 3 RUNX1 3 RYR2 3 SDC4 3 SF3B1 3 SMAD3 3 SMAD4 3 STAT3 3 SUFU 3 SYK 3 TMPRSS2 3 TNFAIP3 3 TSHR 3 ZNF521 3 ADHFE1 2 AKT1 2 AMPH 2 ATAD5 2 AURKA 2 BRINP1 2 BTG1 2 CCND1 2 CCND2 2 CDK12 2 CDK8 2 CDKN1B 2 CHEK2 2 CSF3R 2 CTSA 2 CTSD 2 CYP2C9 2 CYP3A4 2 DROSHA 2 EPHA2 2 ERG 2 EXT2 2 FAM135B 2 FAT2 2 FAT3 2 FGF10 2 FGF14 2 FGF19 2 FGF23 2 FGF3 2 FUBP1 2 GATA1 2 GRM8 2 GSK3B 2 HDAC2 2 HIST1H3H 2 HNRNPA2B1 2 IDH1 2 IDH2 2 KCNB2 2 KDM4D 2 KDM5A 2 LHCGR 2 MDM2 2 MEN1 2 MGAM 2 MLH1 2 MLLT1 2 MRE11A 2 MSH3 2 MTHFR 2 NLGN4X 2 NUP93 2 PCK1 2 PIK3R1 2 PKHD1 2 PLK1 2 POLD1 2 RAD50 2 RAD51B 2 RARA 2 SDHA 2 SMARCA1 2 SMARCB1 2 SOX1 2 SYNE1 2 TGFBR1 2 TLR4 2 TNFRSF19 2 TRIM33 2 TTLL2 2 WT1 2 XPO1 2 ABCC2 1 ABCC6 1 ABL2 1 ACADL 1 ACTR8 1 AFF1 1 AKAP9 1 ALDH2 1 APOB 1 AQP9 1 ARHGAP19 1 ARHGAP6 1 ARHGEF7 1 ARRDC3 1 ASPM 1 AURKB 1 B2M 1 BCL2 1 BCL2L2 1 BCL6 1 BIRC3 1 BIRC5 1 BLM 1 BRD9 1 BTN3A1 1 BUB1B 1 CA9 1 CADM1 1 CALR 1 CARS 1 CASP2 1 CASP9 1 CCNA2 1 CCNB3 1 CCND3 1 CCNE2 1 CD274 1 CD79A 1 CDC73 1 CDH8 1 CDK4 1 CDKN1A 1 CDKN2C 1 CHEK1 1 CLEC1B 1 CLTC 1 COL11A1 1 COL1A1 1 COL1A2 1 CPA1 1 CRKL 1 CRTC1 1 CSF2RB 1 CTSE 1 CYP2B6 1 CYP2C8 1 CYP2D6 1 DAB2IP 1 DAZL 1 DDIT3 1 DPEP1 1 DST 1 E2F1 1 EIF4EBP1 1 ELMO1 1 EML4 1 ERC1 1 ERCC1 1 ERRFI1 1 ESRP1 1 EZR 1 FAM46C 1 FANCA 1 FANCC 1 FANCG 1 FCN1 1 FCRL1 1 FGF4 1 FGFR1 1 FH 1 FLI1 1 FUS 1 GARS 1 GNAQ 1 GPI 1 GRM3 1 GUSB 1 HAL 1 HIST1H3I 1 HNF1A 1 HNF1B 1 HOXC4 1 HRAS 1 IDH3B 1 IL1RL1 1 IL6ST 1 ING1 1 INHBA 1 IRS1 1 ITGA2B 1 KLC1 1 KLF6 1 KLHL6 1 KMO 1 LAMP3 1 LIFR 1 LRIG3 1 LRRC34 1 LRRC4C 1 LTA4H 1 LY96 1 LYN 1 MAGI3 1 MAP2K1 1 MAP2K3 1 MAP2K4 1 MAP3K5 1 MAP3K7 1 MCL1 1 MEP1B 1 MGMT 1 MKI67 1 MLLT4 1 MTRR 1 MUTYH 1 MYCL 1 MYCN 1 NCAM2 1 NEDD4L 1 NNT 1 NPC1 1 NR3C1 1 NRG1 1 NUTM1 1 OBSCN 1 PAK3 1 PARK2 1 PCM1 1 PDCD1 1 PDCD1LG2 1 PDE4B 1 PEG3 1 PFKFB3 1 PGK2 1 PGR 1 PHKG2 1 PIK3C3 1 PLA2G7 1 PLAG1 1 PLCB3 1 PMEL 1 PML 1 PMS1 1 PMS2 1 PPP2CB 1 PRDM1 1 PRKAR1A 1 PRSS1 1 PTPN1 1 PTPRD 1 PTPRG 1 QKI 1 RAC1 1 RAD51 1 RAD51D 1 RAD52 1 RASAL1 1 RASGRF1 1 RHBDF2 1 RHOA 1 RRM1 1 RSPO1 1 RUNX3 1 RUSC1 1 SAMD9L 1 SCN10A 1 SCUBE2 1 SDHAF2 1 SDHB 1 SERPINA7 1 SETBP1 1 SFRP2 1 SHISA5 1 SLC10A1 1 SLC22A1 1 SLC22A2 1 SLC5A8 1 SLCO1B3 1 SLIT1 1 SOS2 1 SOX9 1 SPAG17 1 SPTA1 1 SRC 1 SRCAP 1 SRSF2 1 STAT5A 1 STAT6 1 STS 1 SUCLG1 1 SUCLG2 1 SUZ12 1 SYNE2 1 SYNPO2 1 TBC1D8B 1 TBX5 1 TCF4 1 TEP1 1 TES 1 TEX14 1 TFG 1 THRB 1 TIMP3 1 TKT 1 TLR2 1 TM6SF1 1 TMEM170A 1 TNFRSF14 1 TNRC6B 1 TOP1 1 TOP2A 1 TRPV4 1 TTC36 1 TUBB3 1 UBA1 1 USP9X 1 VEGFA 1 VHL 1 VWF 1 XPC 1 ZBTB17 1 ZIC3 1 ZNF217 1 ZNF331 1 ZNRF3 1