gene number TP53 19 CYLD 6 EP300 6 BRCA2 5 NFKBIA 5 RB1 4 APC 3 ATRX 3 KDM5C 3 KMT2D 3 NOTCH1 3 NOTCH3 3 PIK3CA 3 SETD2 3 SMAD4 3 SPEN 3 TGFBR2 3 ALK 2 ARID1B 2 BAP1 2 BLM 2 CASP8 2 CDKN2A 2 CHEK2 2 CIC 2 CREBBP 2 EPHA3 2 FGF19 2 HIST1H3I 2 IRS2 2 KDM6A 2 KIT 2 KMT2A 2 KMT2C 2 NFE2L2 2 PIK3CB 2 PPP2R1A 2 RET 2 SMARCA4 2 AKT1 1 AMER1 1 AR 1 ARID1A 1 ATR 1 BCL2L11 1 BRAF 1 BRCA1 1 BRD4 1 BRINP3 1 BTG2 1 CA1 1 CBFB 1 CCNE1 1 CD74 1 CDKN1A 1 CDKN2C 1 CYP2A13 1 DICER1 1 EPHA2 1 ERBB3 1 ERBB4 1 ERCC4 1 ERG 1 ETV6 1 FAM135B 1 FANCC 1 FAT1 1 FBXW7 1 FGF3 1 FGF4 1 FGFR2 1 FGFR3 1 FLCN 1 FLT1 1 FLT3 1 FLT4 1 GABBR2 1 GNAS 1 GREM1 1 GRIN2A 1 GRM8 1 IL21R 1 INS-IGF2 1 JAK1 1 JAK2 1 KDM4D 1 KDM5A 1 KEAP1 1 KRAS 1 KSR2 1 LSM14A 1 MLLT1 1 MPL 1 MSH2 1 NF1 1 NKX2-1 1 NLRP3 1 NR1I2 1 NRAS 1 NRG1 1 NSD1 1 NTRK1 1 NTRK2 1 NTRK3 1 PARK2 1 PARP1 1 PDCD1 1 PDGFB 1 PFKL 1 PHOX2B 1 PLCG2 1 PMEL 1 PTEN 1 RAF1 1 RAMP3 1 RICTOR 1 ROS1 1 SDHAF2 1 SENP5 1 SOCS1 1 ST14 1 STAT3 1 STS 1 TERT 1 TET2 1 TGM2 1 TNFAIP3 1 TOE1 1 TOP1 1 TTLL2 1 UGT1A1 1 WHSC1 1 WHSC1L1 1 XRCC6 1