gene number TP53 311 RB1 56 EGFR 53 KEAP1 51 KMT2D 42 FAT1 39 SMARCA4 33 STK11 33 KMT2C 31 APC 30 NOTCH1 28 ATM 27 NF1 27 ERBB4 26 NFE2L2 26 RBM10 26 CDKN2A 25 PIK3CG 25 CREBBP 24 SETD2 24 GNAS 23 ARID1A 22 EPHA5 20 ARID2 19 BRCA2 19 EPHA3 18 EPHB1 18 NTRK3 18 PIK3CA 18 SPEN 18 KIT 17 TET2 17 ALK 16 FBXW7 16 PREX2 16 PTEN 16 DDR2 15 ERBB2 15 NTRK1 15 ROS1 15 BRCA1 14 GRIN2A 14 HGF 14 POLE 14 ARID1B 13 KRAS 13 ATR 12 CARD11 12 KDR 12 DNMT3A 11 DOT1L 11 EP300 11 FLT1 11 KMT2A 11 MET 11 NOTCH3 11 PIK3C2G 11 PLCG2 11 RET 11 SMAD4 11 ATRX 10 CXCR4 10 ESR1 10 GATA3 10 KDM6A 10 MTOR 10 NOTCH2 10 BRAF 9 FLT4 9 IL7R 9 INHBA 9 JAK1 9 JAK2 9 PDGFRA 9 PIK3CB 9 RNF43 9 AMER1 8 AR 8 BARD1 8 FGFR2 8 GATA2 8 MSH6 8 PAX5 8 RICTOR 8 B2M 7 BCOR 7 BRIP1 7 BTK 7 CSF3R 7 ETV1 7 GRM8 7 INPP4B 7 MAP2K1 7 MLH1 7 NSD1 7 NTRK2 7 PBRM1 7 PIK3R1 7 RAF1 7 RPTOR 7 TBX3 7 TERT 7 TSC1 7 ASXL1 6 CBL 6 CSF1R 6 CTNNB1 6 CYLD 6 DICER1 6 ERCC4 6 FGF3 6 GLI1 6 IKBKE 6 IKZF1 6 KDM5A 6 KDM5C 6 MED12 6 MITF 6 NKX2-1 6 PARK2 6 PDGFRB 6 POLD1 6 PPP2R1A 6 TSC2 6 WHSC1L1 6 ZNF521 6 ABCB1 5 BAP1 5 BRD4 5 CDC73 5 CDK4 5 DIS3 5 EPHA7 5 FGFR3 5 FLT3 5 FOXP1 5 GNA13 5 IGF1R 5 IRS2 5 LMO1 5 MSH2 5 MSH3 5 PIK3R2 5 PRDM1 5 PRKAR1A 5 RYR2 5 STAG2 5 STAT3 5 SUFU 5 TCL1A 5 WHSC1 5 ABL1 4 AKT3 4 AXL 4 CASP8 4 CD79B 4 CDK8 4 CEBPA 4 CIC 4 CTCF 4 CYP2C19 4 EML4 4 ETV6 4 FAS 4 FGFR1 4 FH 4 FOXL2 4 FUBP1 4 HNF1A 4 IGF2 4 JAK3 4 MYC 4 NCAM2 4 NFKBIA 4 NLRP3 4 NRAS 4 PALB2 4 PTCH1 4 SF3B1 4 SMO 4 SOX2 4 SPAG17 4 SRC 4 TGFBR2 4 TTK 4 WT1 4 ARAF 3 AXIN1 3 BTG1 3 CCDC178 3 CDH1 3 CDK12 3 CHEK2 3 ERBB3 3 EZH2 3 FAM135B 3 FANCA 3 FANCC 3 FANCG 3 FCRL1 3 FGF4 3 FGFR4 3 GATA1 3 GRM3 3 HRAS 3 IRF4 3 KCNB2 3 MAP3K1 3 MDM2 3 MRE11A 3 MYCN 3 NR4A3 3 PAH 3 PDCD1 3 PTPRD 3 RAD50 3 RUNX1T1 3 SDHA 3 SIGLEC7 3 SLC34A2 3 SMARCA1 3 SPOP 3 TLR4 3 TRPS1 3 XBP1 3 ZFHX4 3 ZIC3 3 ZNF331 3 ADRB2 2 ALDH2 2 BAX 2 BLM 2 BRINP1 2 C11orf30 2 CACNA2D4 2 CALR 2 CBFB 2 CBLB 2 CCNB3 2 CCND2 2 CDH19 2 CDKN1B 2 CHD4 2 CHEK1 2 COL1A2 2 CSMD3 2 DMD 2 DPYD 2 DSE 2 ELMO1 2 ERG 2 FANCE 2 FGF10 2 GNA11 2 GSK3B 2 HIF1A 2 HIST1H3D 2 HIST1H3G 2 IDH2 2 IKZF3 2 JUN 2 KHDRBS2 2 KLHL6 2 KSR2 2 LRP6 2 LZTR1 2 MAP2K4 2 MCL1 2 MEN1 2 MLLT4 2 MMP11 2 NAV3 2 NCOR1 2 NEDD4L 2 NFATC2 2 NT5C2 2 PCK1 2 PDHX 2 PEG3 2 PFKP 2 PLA2G7 2 PMS2 2 PTPN11 2 PTPRT 2 RAD21 2 RAD51 2 RAD51C 2 RAD52 2 RAD54L 2 RARA 2 RASAL1 2 RASGRF2 2 RHOA 2 RUNX1 2 SCD 2 SDHB 2 SH3GL2 2 SLC22A2 2 SLC45A3 2 SMAD2 2 SMAD3 2 SPTA1 2 TBC1D8B 2 TMEM127 2 TNFAIP3 2 TRIM33 2 TSHR 2 VEGFA 2 ABCB11 1 ABCC2 1 ABCC5 1 ACADL 1 ACPP 1 ACSM2A 1 ACVR1B 1 ADAM22 1 ADCY10 1 ADGRA2 1 AFF4 1 AIP 1 AKT1 1 ALDOB 1 ALOX12B 1 ALS2CL 1 AMPH 1 ANTXR2 1 APAF1 1 APOB 1 ARHGAP9 1 ARID5B 1 AURKA 1 BAIAP2L1 1 BAZ2B 1 BCL2 1 BCL6 1 BCR 1 BMPR1A 1 BRINP3 1 BSG 1 BTG2 1 BTN3A1 1 BUB1B 1 CA9 1 CADM1 1 CANT1 1 CCL1 1 CCND3 1 CD1D 1 CD274 1 CD28 1 CD3EAP 1 CDH8 1 CDKN1A 1 CDKN1C 1 CEP57 1 CLEC1B 1 CLIP1 1 CLTC 1 COL11A1 1 COL4A5 1 CPA1 1 CRHBP 1 CST6 1 CTSA 1 CTSE 1 CTSS 1 CUL3 1 CXCL8 1 CYP1A1 1 CYP2B6 1 CYP2E1 1 CYP2R1 1 CYP3A4 1 DAB2IP 1 DDIT3 1 DIDO1 1 DLG4 1 DOCK2 1 DST 1 DVL1 1 EPHA4 1 ESRP1 1 EXT2 1 FAM131B 1 FAM46C 1 FAP 1 FASN 1 FAT3 1 FCGR2A 1 FECH 1 FEV 1 FLCN 1 FLI1 1 FNTA 1 FRS2 1 GABBR2 1 GAK 1 GAPDH 1 GARS 1 GDF7 1 GLO1 1 GNAQ 1 GOLGA5 1 GPC1 1 GPI 1 GRIK1 1 GSTP1 1 GUSB 1 H3F3A 1 HAL 1 HEY1 1 HIST1H3C 1 HIST1H3F 1 HIST1H4A 1 HLA-B 1 HNRNPA2B1 1 HOXB4 1 HPGDS 1 IDH1 1 IDH3G 1 IL2 1 ING1 1 ING2 1 IRF2 1 IRF8 1 ITGA4 1 KRT8 1 L2HGDH 1 LANCL1 1 LIFR 1 LRRC4C 1 LYN 1 MAD1L1 1 MAP2K3 1 MAP2K7 1 MAP3K4 1 MAP3K7 1 MAP4K3 1 MIF 1 MKI67 1 MKRN1 1 MLH3 1 MMP8 1 MPL 1 MTBP 1 MUTYH 1 MYD88 1 MYH9 1 NALCN 1 NBN 1 NCOA1 1 NFASC 1 NLGN4X 1 NR3C2 1 NT5C1A 1 NUP93 1 PAK3 1 PALLD 1 PARP1 1 PCM1 1 PDE10A 1 PDE4B 1 PDE5A 1 PDGFB 1 PDHA1 1 PDK1 1 PFKFB1 1 PFKFB3 1 PGK2 1 PHOX2B 1 PIM1 1 PKD2 1 PKLR 1 PKM 1 PLAG1 1 PMEL 1 POT1 1 PPM1D 1 PRKCB 1 PRKCI 1 PROKR2 1 PTPN1 1 PTPRK 1 PTTG1 1 PYROXD1 1 RAD51B 1 RAD51D 1 RBP2 1 RECQL 1 RECQL4 1 RIPK2 1 ROCK1 1 RRM1 1 RUNX3 1 RXRA 1 SAMD9L 1 SBDS 1 SCUBE2 1 SELL 1 SETD6 1 SFRP1 1 SGK1 1 SIRT2 1 SLC22A12 1 SLC22A16 1 SLCO1B1 1 SOCS1 1 SOX9 1 SS18 1 STAT4 1 STAT5B 1 STOML1 1 STS 1 SUCLG1 1 SUMO1 1 SUZ12 1 SYNE2 1 TBC1D20 1 TCF4 1 TEK 1 TGFBR1 1 THRB 1 TNFRSF11A 1 TOP1 1 TP73 1 TPH2 1 TPI1 1 TRMT61B 1 TTLL5 1 TTR 1 UBA1 1 UGT1A1 1 UGT1A6 1 UMPS 1 USP9X 1 VWF 1 WAS 1 WEE1 1 XPA 1 XPC 1 XPO1 1 XRCC6 1 YAP1 1 ZFHX3 1 ZNRF3 1