gene number TP53 60 BRCA1 7 ARID1A 6 JAK2 6 NF1 6 PTCH1 6 FAT1 5 KDM5C 5 SPEN 5 ARID2 4 PIK3CA 4 ALK 3 ARID1B 3 ATM 3 BLM 3 BRCA2 3 CTNNB1 3 EGFR 3 FBXW7 3 FLT1 3 KMT2C 3 KMT2D 3 MAP3K1 3 NOTCH1 3 NTRK3 3 PBRM1 3 PIK3R1 3 POLE 3 SETD2 3 ACO1 2 AKT1 2 DDR2 2 DIS3 2 EP300 2 EPHA3 2 ERBB2 2 ETV6 2 FGF23 2 FGF3 2 FLT4 2 GLI1 2 GNAS 2 KDM6A 2 KDR 2 KIT 2 KMT2A 2 KRAS 2 MET 2 MSH2 2 NRAS 2 PALB2 2 PIK3CG 2 PTEN 2 RAD50 2 RAD51 2 RAD51D 2 RAD54L 2 RB1 2 SLC34A2 2 SMAD3 2 SMARCA4 2 SPOP 2 ABCC5 1 ABL1 1 ADGRA2 1 AKT2 1 ALOX12B 1 APC 1 AR 1 ASXL1 1 ATR 1 AURKA 1 AXIN1 1 B2M 1 BAIAP2L1 1 BCOR 1 BRAF 1 BRD4 1 BRINP3 1 BRIP1 1 BTK 1 CALR 1 CAMK2A 1 CCBL1 1 CCDC178 1 CCL1 1 CCND3 1 CDH1 1 CDH19 1 CDK12 1 CDKN2B 1 CHEK2 1 CRABP2 1 CREBBP 1 CRKL 1 CSF3R 1 CTCF 1 CYP2A6 1 DDIT3 1 DIDO1 1 DLG4 1 DNMT3A 1 EPHA2 1 EPHA5 1 ERBB3 1 ESR1 1 EZH2 1 FAM46C 1 FANCA 1 FAT2 1 FCRL1 1 FGFR1 1 FN1 1 FUBP1 1 GATA2 1 GRIN2A 1 HGF 1 HIC1 1 HNF1A 1 HNF1B 1 IDH2 1 IGF1R 1 IKZF1 1 JAK3 1 KDM5A 1 KEAP1 1 KMT2B 1 LDHAL6B 1 LGALS3 1 LY96 1 MDM2 1 MED12 1 MGAM 1 MKI67 1 MLH1 1 MLLT4 1 MMP16 1 MSH6 1 MYC 1 NACC1 1 NCAM2 1 NCOR1 1 NFE2L2 1 NLRP3 1 NOTCH3 1 NT5C2 1 NTRK1 1 NUP93 1 PARP2 1 PDCD1 1 PDGFRA 1 PDK2 1 PFKFB1 1 PFKFB2 1 PFKFB3 1 PGR 1 PIK3C2G 1 PLAU 1 PMM2 1 POLD1 1 PRF1 1 RAF1 1 RARA 1 REV3L 1 RNF128 1 ROS1 1 RPTOR 1 RRAS2 1 RUNX1 1 SF3B1 1 SLC28A2 1 SLIT1 1 SMARCA1 1 SMS 1 SPAG17 1 SRSF2 1 STAT3 1 TBX3 1 TERT 1 TES 1 TET2 1 TGFBR2 1 TNFRSF14 1 TOP2A 1 TP73 1 TPH2 1 TSC1 1 XPC 1 XPO1 1 ZNF217 1 ZNF276 1