gene number TP53 77 SMAD4 24 ARID1A 11 CDKN2A 11 KRAS 9 RB1 6 RNF43 6 SETD2 5 ATM 4 BRAF 4 CREBBP 4 KDM6A 4 NF1 4 SMARCA4 4 APC 3 FAT1 3 GNAS 3 IKBKE 3 KDM5A 3 KEAP1 3 KIT 3 LMO1 3 MAP2K4 3 MSH6 3 NTRK3 3 PIK3CA 3 SMAD3 3 SPEN 3 TGFBR1 3 TSC2 3 ARID2 2 BAP1 2 BCOR 2 BRINP1 2 CASP8 2 CBLB 2 CDKN1B 2 CRKL 2 CSF1R 2 EGFR 2 EP300 2 EPHA3 2 ETV6 2 FANCA 2 FAS 2 FBXW7 2 HGF 2 JAK2 2 KDR 2 KHDRBS2 2 KMT2C 2 KMT2D 2 MTOR 2 NEK8 2 NKX2-1 2 NOTCH1 2 NOTCH3 2 PBRM1 2 PIK3CG 2 POLE 2 PPP2R1A 2 RAF1 2 RARA 2 RBM10 2 RPTOR 2 SOCS1 2 TERT 2 TGFBR2 2 TSC1 2 WHSC1 2 WT1 2 ACVR1B 1 ACVR2A 1 ACVR2B 1 AKT3 1 ALK 1 APOB 1 AR 1 ARAF 1 ARID1B 1 ATR 1 ATRX 1 AXIN1 1 B2M 1 BAIAP2L1 1 BCL2 1 BCL2L1 1 BRCA2 1 BRINP3 1 BTK 1 CASP2 1 CASP9 1 CBL 1 CBR1 1 CCND2 1 CCND3 1 CD74 1 CDH19 1 CHEK2 1 CIC 1 CSMD3 1 CTNNB1 1 CXCR4 1 CYLD 1 CYP3A5 1 D2HGDH 1 EPHA4 1 EPHB1 1 ERBB4 1 ERCC2 1 ERG 1 ETV1 1 FAM46C 1 FANCC 1 FBXO11 1 FES 1 FGFR3 1 FLT1 1 FLT3 1 FOXL2 1 FOXP1 1 GDF7 1 GRM8 1 HNF1A 1 HNF1B 1 IDH1 1 IRS2 1 JAK1 1 KMT2A 1 KMT2B 1 LDHB 1 MAGI2 1 MAP2K1 1 MAP2K3 1 MAP3K7 1 MDM4 1 MED12 1 MEN1 1 MKI67 1 MPL 1 MRE11A 1 MSN 1 MTR 1 MYC 1 NBN 1 NFASC 1 NLRP3 1 NT5C2 1 NTRK2 1 PALB2 1 PARP1 1 PAX5 1 PDGFRA 1 PDK3 1 PEG3 1 PIK3R1 1 PIM1 1 PLCG2 1 PLK1 1 POLK 1 PPHLN1 1 PREX2 1 PRKCI 1 PROKR2 1 PTEN 1 RAD50 1 RAD51B 1 RAD51C 1 RAD51D 1 RET 1 RHOA 1 RICTOR 1 RPS6KB1 1 SF3B1 1 SLC34A2 1 SLIT1 1 SLX4 1 SMAD2 1 SRC 1 STK11 1 SYNE1 1 TEP1 1 TMPRSS2 1 TNFRSF14 1 TOP1 1 TPBG 1 TPMT 1 TSHR 1 UBR5 1 VEGFA 1 XIRP1 1 ZFHX4 1 ZNF331 1 ZNF444 1 ZNF521 1 ZNRF3 1