gene number APC 140 TP53 130 SMAD4 40 FBXW7 30 GNAS 17 KRAS 16 PIK3CA 15 ATM 13 KMT2C 13 ARID1A 11 AMER1 10 PIK3R1 10 SOX9 10 BRCA2 9 EP300 8 FAT1 8 JUN 8 KMT2A 8 KMT2D 8 PREX2 8 ARID2 7 ASXL1 7 CARD11 7 CTNNB1 7 EGFR 7 EPHA5 7 ERBB4 7 NOTCH1 7 NRAS 7 RNF43 7 EPHA3 6 KDR 6 NTRK1 6 RICTOR 6 SMAD3 6 WHSC1 6 ATRX 5 ERBB2 5 ERBB3 5 ETV6 5 GRIN2A 5 NF1 5 NOTCH2 5 NTRK3 5 PIK3C2G 5 PIK3CG 5 POLE 5 PTEN 5 SPEN 5 TGFBR2 5 AR 4 AXL 4 BCOR 4 BRAF 4 CDK8 4 CREBBP 4 EPHA7 4 EPHB1 4 FGFR1 4 FLT1 4 KDM5C 4 KIT 4 NOTCH3 4 PARK2 4 RB1 4 ROS1 4 ABL1 3 ALK 3 CASP8 3 CXCR4 3 DNMT3A 3 ESR1 3 GLI1 3 HGF 3 IGF1R 3 JAK1 3 KDM6A 3 MAP2K1 3 MAP2K4 3 MSH6 3 MTOR 3 NTRK2 3 NUP93 3 PBRM1 3 PDGFRA 3 PLCG2 3 RBM10 3 SETD2 3 SMAD2 3 SMARCB1 3 SMO 3 TERT 3 TET2 3 TSC2 3 AKT1 2 ATR 2 B2M 2 BCL2 2 BRCA1 2 BRD4 2 BTK 2 CDH1 2 CDK12 2 CSMD3 2 CTCF 2 DDR2 2 DIS3 2 DPYD 2 FANCA 2 FAS 2 FGFR4 2 FH 2 FLT3 2 FOXP1 2 GATA3 2 IDH2 2 IL7R 2 JAK2 2 KDM5A 2 KEAP1 2 LIG4 2 LMO1 2 LYN 2 MACC1 2 MAP2K7 2 MAP3K1 2 MET 2 MITF 2 MKI67 2 MSH3 2 MUTYH 2 MYC 2 NALCN 2 NKX2-1 2 NLRP3 2 NRG1 2 NSD1 2 PAX5 2 PCK1 2 PDGFRB 2 POLD1 2 PPP2R1A 2 PRKAR1A 2 PTCH1 2 RAD51B 2 RET 2 RHOA 2 SH2B3 2 SMARCA4 2 STAG2 2 STAT3 2 TCF7L2 2 TRIM24 2 TSC1 2 WHSC1L1 2 ABCC9 1 ACADL 1 ACVR1B 1 ACVR2A 1 AFF1 1 ALOX12B 1 ARID1B 1 ARID5B 1 ARRDC3 1 ATIC 1 AXIN1 1 BAP1 1 BARD1 1 BRINP1 1 BRINP3 1 BTRC 1 CCNB2 1 CCND1 1 CCND2 1 CCND3 1 CCNE1 1 CDH19 1 CDK2 1 CDKN2A 1 CDKN2B 1 CEBPA 1 CLTC 1 COL1A2 1 CRKL 1 CSF1R 1 CYLD 1 CYP1A1 1 CYP2A7 1 CYP2C9 1 CYP3A4 1 DCTN1 1 DICER1 1 DMD 1 DOCK2 1 DOT1L 1 ERCC1 1 ERCC4 1 EREG 1 ERRFI1 1 ETV4 1 EZH2 1 FANCG 1 FAT3 1 FAT4 1 FBXO11 1 FCRL1 1 FGF14 1 FGFR2 1 FLCN 1 FLT4 1 FOXL2 1 FTSJ2 1 GABRA6 1 GATA1 1 GDF7 1 GNA13 1 GSK3B 1 GSS 1 HIST1H3B 1 HIST1H3I 1 HLA-B 1 HNRNPA2B1 1 HOXC4 1 HRAS 1 IDH1 1 IKBKE 1 IKZF1 1 IKZF3 1 INHBA 1 INS-IGF2 1 IRF4 1 IRS2 1 ITGB2 1 JAG1 1 JAK3 1 KHDRBS2 1 KLC1 1 LANCL1 1 MAD1L1 1 MAP2K3 1 MAP4K3 1 MAX 1 MDM4 1 MED12 1 MEP1B 1 MLH1 1 MMP11 1 MRE11A 1 MYCL 1 NCAM2 1 NCOA1 1 NFKBIA 1 NR1I3 1 NR3C1 1 NR4A3 1 NT5C2 1 PALB2 1 PARP1 1 PC 1 PDCD1 1 PDE10A 1 PDGFB 1 PEG3 1 PFKP 1 PHKG2 1 PIK3CB 1 PIK3R2 1 PKLR 1 PLK1 1 PMS2 1 PNMT 1 PRDM1 1 PTPN11 1 PTPRB 1 PTPRD 1 PTPRG 1 RAD50 1 RAD51 1 RAD51D 1 RAD52 1 RAF1 1 RBP2 1 RNF128 1 RORC 1 RPTOR 1 RUNX1 1 SBDS 1 SDHB 1 SF3B1 1 SFRP1 1 SGK1 1 SHISA5 1 SLC28A3 1 SLC45A3 1 SOCS1 1 SOX2 1 SPTA1 1 SRC 1 STRN 1 SUFU 1 SYK 1 TBC1D20 1 TCL1A 1 TEK 1 THADA 1 THRB 1 TLR2 1 TLR4 1 TNFAIP3 1 TNFRSF10D 1 TNFRSF11A 1 TNFRSF14 1 TNNC1 1 TPMT 1 TRIM33 1 TTLL2 1 UBE3C 1 VEGFA 1 WAS 1 WEE1 1 WNT4 1 WT1 1 XPO1 1 ZIC3 1 ZNF444 1 ZNRF3 1