gene number TP53 12 KEAP1 3 KRAS 3 APC 2 NOTCH1 2 RB1 2 ARID1A 1 ARID1B 1 ATRX 1 BRAF 1 BRD4 1 BTK 1 CDH1 1 CDH19 1 CDKN2A 1 CEBPA 1 DDR2 1 DNMT3A 1 ERBB4 1 FHIT 1 FLT3 1 HNF1A 1 IKBKE 1 JAK2 1 KEL 1 MEN1 1 MPL 1 MSH2 1 MSH3 1 NCOA1 1 NSD1 1 NTRK2 1 PALB2 1 PBRM1 1 PDGFRA 1 PIK3CB 1 PIK3CG 1 PKHD1 1 PMS2 1 RBM10 1 SMO 1 STAG2 1 STK11 1 TSC2 1 WHSC1L1 1