gene number TP53 131 RB1 86 KMT2D 32 FAT1 28 NOTCH1 26 APC 19 CREBBP 15 EP300 15 ERBB4 15 GRIN2A 13 PIK3CA 13 ROS1 12 EPHA5 11 KMT2C 11 BRCA2 10 EPHA3 10 NOTCH3 10 PTCH1 10 ALK 9 FLT3 9 GNAS 9 PREX2 9 ATR 8 KEAP1 8 NF1 8 ABL1 7 AMER1 7 ATM 7 BCOR 7 EGFR 7 FBXW7 7 FLT1 7 PDGFRA 7 PIK3CG 7 SMARCA4 7 ARID1A 6 ARID2 6 BRCA1 6 FLT4 6 HGF 6 INHBA 6 INPP4B 6 TSC2 6 ATRX 5 DOT1L 5 DPYD 5 IRF4 5 JAK2 5 KDR 5 KMT2A 5 MET 5 NSD1 5 NTRK2 5 PIK3C2G 5 SETD2 5 STAG2 5 ABCB1 4 ARID1B 4 BRIP1 4 CARD11 4 DDR2 4 DICER1 4 ESR1 4 GATA3 4 KDM6A 4 MDM4 4 MED12 4 POLD1 4 PTEN 4 RET 4 RYR2 4 TBX3 4 ZNF521 4 B2M 3 CASP8 3 CDK8 3 CDKN2A 3 CIC 3 EPHB1 3 ERBB2 3 FUBP1 3 IDH2 3 IGF2 3 KDM5C 3 KIT 3 MTOR 3 NOTCH2 3 NTRK3 3 PALB2 3 PARP1 3 PBRM1 3 PDGFRB 3 PIK3CB 3 RBM10 3 RICTOR 3 RNF43 3 RPTOR 3 SOX9 3 SRC 3 TSHR 3 WHSC1L1 3 WT1 3 AKT1 2 AKT2 2 AR 2 BAP1 2 CBL 2 CCND2 2 CDKN1B 2 COL11A1 2 CUL3 2 CYLD 2 DNMT3A 2 EPHA7 2 ERCC4 2 ERG 2 ETV1 2 FGFR2 2 FOXP1 2 GATA1 2 GATA2 2 GLI1 2 GNA11 2 GSTP1 2 HIC1 2 HIF1A 2 HNF1A 2 HRAS 2 IGF1R 2 IKBKE 2 IL7R 2 JAK1 2 JAK3 2 KDM5A 2 KHDRBS2 2 LRRC4C 2 LY86 2 LYN 2 MAP2K1 2 MED23 2 MEP1B 2 MKI67 2 MLH1 2 NFE2L2 2 NLRP3 2 NPM1 2 PARK2 2 PAX5 2 PDCD1 2 PKM 2 PLCG2 2 POLE 2 PPP2R1A 2 PTPRB 2 RAD50 2 RAD51 2 RARA 2 RUNX1T1 2 SELL 2 SF3B1 2 SMO 2 SPEN 2 SYK 2 TBX5 2 TET2 2 TGFBR2 2 TGM2 2 TNFAIP3 2 TP73 2 TRPS1 2 WHSC1 2 WNT11 2 WRN 2 ZFHX4 2 ABCC11 1 ABL2 1 ACE 1 ACVR1B 1 ADGRA2 1 ADH1B 1 AKT3 1 AMPH 1 ARAF 1 ASXL1 1 AXL 1 BARD1 1 BAX 1 BAZ2B 1 BLM 1 BRAF 1 BRD4 1 BRINP1 1 BTG2 1 BTK 1 BTRC 1 CCND1 1 CCND3 1 CD274 1 CDH1 1 CDK12 1 CDK6 1 CDK7 1 CDKN1A 1 CDKN2B 1 CHEK2 1 CLEC1B 1 CLIP1 1 COL4A1 1 CPA4 1 CREB1 1 CRKL 1 CSDE1 1 CSF1R 1 CSF3R 1 CSMD3 1 CTNNB1 1 CTSE 1 CXCL8 1 CXCR4 1 CYP19A1 1 CYP2B6 1 CYP2C19 1 DAB2IP 1 DCK 1 DIS3 1 DOCK2 1 ENO3 1 EPHA2 1 ERBB3 1 EXT1 1 EZH2 1 FANCA 1 FANCE 1 FAP 1 FAS 1 FASLG 1 FAT2 1 FCGR2A 1 FCN1 1 FCRL1 1 FDPS 1 FES 1 FGF10 1 FGF19 1 FGF3 1 FGFR1 1 FGFR3 1 FGFR4 1 FH 1 FIBCD1 1 FOXL2 1 FRS2 1 GABRA6 1 GAPDHS 1 GCK 1 GNA13 1 GRM8 1 HADH 1 HIST1H3H 1 HOOK3 1 HPDL 1 HSD3B1 1 IRF2 1 IRS1 1 IRS2 1 ITGA4 1 JUN 1 LAMP3 1 LHCGR 1 LMO1 1 LRP1B 1 LRP5 1 LTA4H 1 LZTR1 1 MAP2K3 1 MAP2K4 1 MAP2K7 1 MAP3K1 1 MAP4K3 1 MAPK1 1 MAPK11 1 MAX 1 MCL1 1 MEN1 1 MITD1 1 MMP13 1 MSH2 1 MSH3 1 MST1R 1 MTHFR 1 MUTYH 1 MYC 1 MYCN 1 MYH9 1 NALCN 1 NAV3 1 NBN 1 NCAM2 1 NFASC 1 NFKBIA 1 NPY 1 NRAS 1 NTRK1 1 NUP93 1 OBSCN 1 OTOP1 1 PDE10A 1 PDK3 1 PDPK1 1 PEG3 1 PFKFB1 1 PGK2 1 PHOX2B 1 PIGF 1 PIK3R1 1 PLAU 1 PML 1 PMS2 1 PPIP5K2 1 PTPRK 1 PUS1 1 PYGM 1 RAD21 1 RAD51C 1 RAD52 1 RANBP2 1 RASAL1 1 RBP4 1 RIPK2 1 RPS6KC1 1 RUNX3 1 SCN10A 1 SDHB 1 SH2B3 1 SH3GL2 1 SLC10A1 1 SLC22A16 1 SLC22A2 1 SLC22A4 1 SMAD2 1 SMARCB1 1 SOD2 1 SOX2 1 SPOP 1 STX5 1 SUFU 1 TACC1 1 TCF4 1 TCL1A 1 TEP1 1 TFG 1 TLR2 1 TLR4 1 TMEM51 1 TOP1 1 TRIM33 1 TSC1 1 TTK 1 UBE2D2 1 USP9X 1 XPA 1 XPO1 1 ZC3H13 1