CAZy,CAZy,CAZy,CAZy,CAZy,CAZy,CAZy,CAZy,CAZy,CAZy,carbohydrate-active,enzymes,database,,CAZy,,2013,Carbohydrate-Active,Enzymes,database,,CAZy;,http://www.cazy.org,,provides,online,continuously,updated,access,sequence-based,family,classification,linking,sequence,specificity,3D,structure,enzymes,assemble,,modify,breakdown,oligo-,polysaccharides,Functional,3D,structural,information,added,curated,regular,basis,based,available,literature,addition,use,database,enzymologists,seeking,curated,information,CAZymes,,dissemination,stable,nomenclature,enzymes,probably,major,contribution,CAZy,past,years,seen,expansion,CAZy,classification,scheme,new,families,,development,subfamilies,several,families,power,CAZy,analysis,genomes,metagenomes,article,outlines,changes,occurred,CAZy,past,5,years,presents,novel,effort,display,resolution,carbohydrate,ligands,crystallographic,complexes,CAZymes,Carbohydrate-Active,EnZymes,database,,CAZy,:,expert,resource,Glycogenomics,Carbohydrate-Active,Enzyme,,CAZy,,database,knowledge-based,resource,specialized,enzymes,build,breakdown,complex,carbohydrates,glycoconjugates,September,2008,,database,describes,present,knowledge,113,glycoside,hydrolase,,91,glycosyltransferase,,19,polysaccharide,lyase,,15,carbohydrate,esterase,52,carbohydrate-binding,module,families,families,created,based,experimentally,characterized,proteins,populated,sequences,public,databases,significant,similarity,Protein,biochemical,information,continuously,curated,based,available,literature,structural,information,6400,proteins,assigned,EC,numbers,700,proteins,PDB,structure,classification,,,reflects,structural,features,enzymes,better,sole,substrate,specificity,,,ii,,helps,reveal,evolutionary,relationships,enzymes,,iii,,provides,convenient,framework,understand,mechanistic,properties,resource,available,10,years,scientific,community,,contributing,information,dissemination,providing,transversal,nomenclature,glycobiologists,recently,,resource,used,improve,quality,functional,predictions,number,genome,projects,providing,expert,annotation,CAZy,resource,resides,URL:,http://www.cazy.org/.<br>Ten,years,CAZypedia:,living,encyclopedia,carbohydrate-active,enzymes,CAZypedia,initiated,2007,create,comprehensive,,living,encyclopedia,carbohydrate-active,enzymes,,CAZymes,,associated,carbohydrate-binding,modules,involved,synthesis,,modification,degradation,complex,carbohydrates,CAZypedia,closely,connected,actively,curated,CAZy,database,,provides,sequence-based,foundation,biochemical,,mechanistic,structural,characterization,diverse,proteins,Now,celebrating,10th,anniversary,online,,CAZypedia,successful,example,dynamic,,community-driven,expert-based,biocuration,CAZypedia,open-access,resource,available,URL,http://www.cazypedia.org.<br>Starch-binding,domains,CBM,families-history,,occurrence,,structure,,function,evolution,term,"starch-binding,domain",,SBD,,applied,domain,within,amylolytic,enzyme,gave,enzyme,ability,bind,onto,raw,,i.e,thermally,untreated,,granular,starch,SBD,special,case,carbohydrate-binding,domain,,general,,structurally,functionally,independent,protein,module,exhibiting,enzymatic,activity,possessing,potential,target,catalytic,domain,carbohydrate,substrate,accommodate,process,active,site,so-called,families,,SBDs,together,carbohydrate-binding,modules,,CBMs,,become,integral,part,CAZy,database,,http://www.cazy.org/,,first,two,well-described,SBDs,,i.e,C-terminal,Aspergillus-type,N-terminal,Rhizopus-type,assigned,families,CBM20,CBM21,,respectively,Currently,,among,85,established,CBM,families,CAZy,,fifteen,can,considered,families,SBD,functional,characteristics:,CBM20,,21,,25,,26,,34,,41,,45,,48,,53,,58,,68,,69,,74,,82,83,known,SBDs,,exception,extra,long,CBM74,,recognized,module,consisting,approximately,100,residues,,adopting,β-sandwich,fold,possessing,least,one,carbohydrate-binding,site,present,review,aims,deliver,describe:,,,SBD,identification,different,amylolytic,related,enzymes,,e.g.,,CAZy,GH,families,,well,relevant,enzymes,proteins,,e.g.,,laforin,,β-subunit,AMPK,,others,;,,ii,,information,position,polypeptide,chain,number,SBD,copies,CBM,family,affiliation,,appropriate,;,,iii,,structure/function,studies,SBDs,special,focus,solved,tertiary,structures,,particular,,complexes,α-glucan,ligands;,,iv,,evolutionary,relationships,SBDs,tree,common,SBD,CBM,families,,except,extra,long,CBM74,,Finally,,special,cases,novel,potential,SBDs,also,introduced.<br>,carbohydrate-active,enzymes,database,,CAZy,,2013,Carbohydrate-Active,Enzymes,database,,CAZy;,http://www.cazy.org,,provides,online,continuously,updated,access,sequence-based,family,classification,linking,sequence,specificity,3D,structure,enzymes,assemble,,modify,breakdown,oligo-,polysaccharides,Functional,3D,structural,information,added,curated,regular,basis,based,available,literature,addition,use,database,enzymologists,seeking,curated,information,CAZymes,,dissemination,stable,nomenclature,enzymes,probably,major,contribution,CAZy,past,years,seen,expansion,CAZy,classification,scheme,new,families,,development,subfamilies,several,families,power,CAZy,analysis,genomes,metagenomes,article,outlines,changes,occurred,CAZy,past,5,years,presents,novel,effort,display,resolution,carbohydrate,ligands,crystallographic,complexes,CAZymes,Carbohydrate-Active,EnZymes,database,,CAZy,:,expert,resource,Glycogenomics,Carbohydrate-Active,Enzyme,,CAZy,,database,knowledge-based,resource,specialized,enzymes,build,breakdown,complex,carbohydrates,glycoconjugates,September,2008,,database,describes,present,knowledge,113,glycoside,hydrolase,,91,glycosyltransferase,,19,polysaccharide,lyase,,15,carbohydrate,esterase,52,carbohydrate-binding,module,families,families,created,based,experimentally,characterized,proteins,populated,sequences,public,databases,significant,similarity,Protein,biochemical,information,continuously,curated,based,available,literature,structural,information,6400,proteins,assigned,EC,numbers,700,proteins,PDB,structure,classification,,,reflects,structural,features,enzymes,better,sole,substrate,specificity,,,ii,,helps,reveal,evolutionary,relationships,enzymes,,iii,,provides,convenient,framework,understand,mechanistic,properties,resource,available,10,years,scientific,community,,contributing,information,dissemination,providing,transversal,nomenclature,glycobiologists,recently,,resource,used,improve,quality,functional,predictions,number,genome,projects,providing,expert,annotation,CAZy,resource,resides,URL:,http://www.cazy.org/.<br>Ten,years,CAZypedia:,living,encyclopedia,carbohydrate-active,enzymes,CAZypedia,initiated,2007,create,comprehensive,,living,encyclopedia,carbohydrate-active,enzymes,,CAZymes,,associated,carbohydrate-binding,modules,involved,synthesis,,modification,degradation,complex,carbohydrates,CAZypedia,closely,connected,actively,curated,CAZy,database,,provides,sequence-based,foundation,biochemical,,mechanistic,structural,characterization,diverse,proteins,Now,celebrating,10th,anniversary,online,,CAZypedia,successful,example,dynamic,,community-driven,expert-based,biocuration,CAZypedia,open-access,resource,available,URL,http://www.cazypedia.org.<br>Starch-binding,domains,CBM,families-history,,occurrence,,structure,,function,evolution,term,"starch-binding,domain",,SBD,,applied,domain,within,amylolytic,enzyme,gave,enzyme,ability,bind,onto,raw,,i.e,thermally,untreated,,granular,starch,SBD,special,case,carbohydrate-binding,domain,,general,,structurally,functionally,independent,protein,module,exhibiting,enzymatic,activity,possessing,potential,target,catalytic,domain,carbohydrate,substrate,accommodate,process,active,site,so-called,families,,SBDs,together,carbohydrate-binding,modules,,CBMs,,become,integral,part,CAZy,database,,http://www.cazy.org/,,first,two,well-described,SBDs,,i.e,C-terminal,Aspergillus-type,N-terminal,Rhizopus-type,assigned,families,CBM20,CBM21,,respectively,Currently,,among,85,established,CBM,families,CAZy,,fifteen,can,considered,families,SBD,functional,characteristics:,CBM20,,21,,25,,26,,34,,41,,45,,48,,53,,58,,68,,69,,74,,82,83,known,SBDs,,exception,extra,long,CBM74,,recognized,module,consisting,approximately,100,residues,,adopting,β-sandwich,fold,possessing,least,one,carbohydrate-binding,site,present,review,aims,deliver,describe:,,,SBD,identification,different,amylolytic,related,enzymes,,e.g.,,CAZy,GH,families,,well,relevant,enzymes,proteins,,e.g.,,laforin,,β-subunit,AMPK,,others,;,,ii,,information,position,polypeptide,chain,number,SBD,copies,CBM,family,affiliation,,appropriate,;,,iii,,structure/function,studies,SBDs,special,focus,solved,tertiary,structures,,particular,,complexes,α-glucan,ligands;,,iv,,evolutionary,relationships,SBDs,tree,common,SBD,CBM,families,,except,extra,long,CBM74,,Finally,,special,cases,novel,potential,SBDs,also,introduced.<br>