dbCAN,dbCAN,dbCAN,dbCAN,dbCAN,dbCAN,dbCAN,dbCAN,dbCAN,dbCAN,dbCAN:,web,resource,automated,carbohydrate-active,enzyme,annotation,Carbohydrate-active,enzymes,,CAZymes,,important,biotech,industry,,particularly,emerging,biofuel,industry,CAZymes,responsible,synthesis,,degradation,modification,carbohydrates,Earth,developed,web,resource,,dbCAN,,http://csbl.bmb.uga.edu/dbCAN/annotate.php,,,provide,capability,automated,CAZyme,signature,domain-based,annotation,given,protein,data,set,,e.g,proteins,newly,sequenced,genome,,submitted,server,accomplish,,explicitly,defined,signature,domain,every,CAZyme,family,,derived,based,CDD,,conserved,domain,database,,search,literature,curation,also,constructed,hidden,Markov,model,represent,signature,domain,CAZyme,family,CAZyme,family-specific,HMMs,key,contribution,foundation,automated,CAZyme,annotation.<br>dbCAN2:,meta,server,automated,carbohydrate-active,enzyme,annotation,Complex,carbohydrates,plants,main,food,sources,animals,microbes,,serve,promising,renewable,feedstock,biofuel,biomaterial,production,Carbohydrate,active,enzymes,,CAZymes,,important,enzymes,complex,carbohydrate,metabolism,increasing,number,plant,plant-associated,microbial,genomes,metagenomes,sequenced,,urgent,need,automatic,tools,genomic,data,mining,CAZymes,developed,dbCAN,web,server,2012,provide,public,service,automated,CAZyme,annotation,newly,sequenced,genomes,,dbCAN2,,http://cys.bios.niu.edu/dbCAN2,,presented,updated,meta,server,,integrates,three,state-of-the-art,tools,CAZome,,CAZymes,genome,,annotation:,,,HMMER,search,dbCAN,HMM,,hidden,Markov,model,,database;,,ii,,DIAMOND,search,CAZy,pre-annotated,CAZyme,sequence,database,,iii,,Hotpep,search,conserved,CAZyme,short,peptide,database,Combining,three,outputs,removing,CAZymes,found,one,tool,can,significantly,improve,CAZome,annotation,accuracy,addition,,dbCAN2,now,also,accepts,nucleotide,sequence,submission,,offers,service,predict,physically,linked,CAZyme,gene,clusters,,CGCs,,,will,useful,online,tool,identifying,putative,polysaccharide,utilization,loci,,PULs,,microbial,genomes,metagenomes.dbCAN3:,automated,carbohydrate-active,enzyme,substrate,annotation,Carbohydrate,active,enzymes,,CAZymes,,made,various,organisms,complex,carbohydrate,metabolism,Genome,mining,CAZymes,become,routine,data,analysis,,meta-,genome,projects,,owing,importance,CAZymes,bioenergy,,microbiome,,nutrition,,agriculture,,global,carbon,recycling,2012,,dbCAN,provided,online,web,server,automated,CAZyme,annotation,dbCAN2,,https://bcb.unl.edu/dbCAN2,,developed,2018,meta,server,combine,multiple,tools,improved,CAZyme,annotation,dbCAN2,also,included,CGC-Finder,,tool,identifying,CAZyme,gene,clusters,,CGCs,,,meta-,genomes,updated,meta,server,dbCAN3,following,new,functions,components:,,,dbCAN-sub,profile,Hidden,Markov,Model,database,,HMMdb,,substrate,prediction,CAZyme,subfamily,level;,,ii,,searching,experimentally,characterized,polysaccharide,utilization,loci,,PULs,,known,glycan,substates,dbCAN-PUL,database,substrate,prediction,CGC,level;,,iii,,majority,voting,method,consider,CAZymes,substrate,predicted,dbCAN-sub,substrate,prediction,CGC,level;,,iv,,improved,data,browsing,visualization,substrate,prediction,results,website,summary,,dbCAN3,inherits,functions,dbCAN2,,also,integrates,three,new,methods,glycan,substrate,prediction.<br>,dbCAN:,web,resource,automated,carbohydrate-active,enzyme,annotation,Carbohydrate-active,enzymes,,CAZymes,,important,biotech,industry,,particularly,emerging,biofuel,industry,CAZymes,responsible,synthesis,,degradation,modification,carbohydrates,Earth,developed,web,resource,,dbCAN,,http://csbl.bmb.uga.edu/dbCAN/annotate.php,,,provide,capability,automated,CAZyme,signature,domain-based,annotation,given,protein,data,set,,e.g,proteins,newly,sequenced,genome,,submitted,server,accomplish,,explicitly,defined,signature,domain,every,CAZyme,family,,derived,based,CDD,,conserved,domain,database,,search,literature,curation,also,constructed,hidden,Markov,model,represent,signature,domain,CAZyme,family,CAZyme,family-specific,HMMs,key,contribution,foundation,automated,CAZyme,annotation.<br>dbCAN2:,meta,server,automated,carbohydrate-active,enzyme,annotation,Complex,carbohydrates,plants,main,food,sources,animals,microbes,,serve,promising,renewable,feedstock,biofuel,biomaterial,production,Carbohydrate,active,enzymes,,CAZymes,,important,enzymes,complex,carbohydrate,metabolism,increasing,number,plant,plant-associated,microbial,genomes,metagenomes,sequenced,,urgent,need,automatic,tools,genomic,data,mining,CAZymes,developed,dbCAN,web,server,2012,provide,public,service,automated,CAZyme,annotation,newly,sequenced,genomes,,dbCAN2,,http://cys.bios.niu.edu/dbCAN2,,presented,updated,meta,server,,integrates,three,state-of-the-art,tools,CAZome,,CAZymes,genome,,annotation:,,,HMMER,search,dbCAN,HMM,,hidden,Markov,model,,database;,,ii,,DIAMOND,search,CAZy,pre-annotated,CAZyme,sequence,database,,iii,,Hotpep,search,conserved,CAZyme,short,peptide,database,Combining,three,outputs,removing,CAZymes,found,one,tool,can,significantly,improve,CAZome,annotation,accuracy,addition,,dbCAN2,now,also,accepts,nucleotide,sequence,submission,,offers,service,predict,physically,linked,CAZyme,gene,clusters,,CGCs,,,will,useful,online,tool,identifying,putative,polysaccharide,utilization,loci,,PULs,,microbial,genomes,metagenomes.dbCAN3:,automated,carbohydrate-active,enzyme,substrate,annotation,Carbohydrate,active,enzymes,,CAZymes,,made,various,organisms,complex,carbohydrate,metabolism,Genome,mining,CAZymes,become,routine,data,analysis,,meta-,genome,projects,,owing,importance,CAZymes,bioenergy,,microbiome,,nutrition,,agriculture,,global,carbon,recycling,2012,,dbCAN,provided,online,web,server,automated,CAZyme,annotation,dbCAN2,,https://bcb.unl.edu/dbCAN2,,developed,2018,meta,server,combine,multiple,tools,improved,CAZyme,annotation,dbCAN2,also,included,CGC-Finder,,tool,identifying,CAZyme,gene,clusters,,CGCs,,,meta-,genomes,updated,meta,server,dbCAN3,following,new,functions,components:,,,dbCAN-sub,profile,Hidden,Markov,Model,database,,HMMdb,,substrate,prediction,CAZyme,subfamily,level;,,ii,,searching,experimentally,characterized,polysaccharide,utilization,loci,,PULs,,known,glycan,substates,dbCAN-PUL,database,substrate,prediction,CGC,level;,,iii,,majority,voting,method,consider,CAZymes,substrate,predicted,dbCAN-sub,substrate,prediction,CGC,level;,,iv,,improved,data,browsing,visualization,substrate,prediction,results,website,summary,,dbCAN3,inherits,functions,dbCAN2,,also,integrates,three,new,methods,glycan,substrate,prediction.<br>