HumanNet,HumanNet,HumanNet,HumanNet,HumanNet,HumanNet,HumanNet,HumanNet,HumanNet,HumanNet,HumanNet,v2:,human,gene,networks,disease,research,Human,gene,networks,proven,useful,many,aspects,disease,research,,numerous,network-based,strategies,developed,generating,hypotheses,gene-disease-drug,associations,ability,predict,organize,genes,relevant,specific,disease,proven,especially,important,previously,developed,human,functional,gene,network,,HumanNet,,integrating,diverse,types,omics,data,using,Bayesian,statistics,framework,demonstrated,ability,retrieve,disease,genes,,present,HumanNet,v2,,http://www.inetbio.org/humannet,,,database,human,gene,networks,,updated,incorporating,new,data,types,,extending,data,sources,improving,network,inference,algorithms,HumanNet,now,comprises,hierarchy,human,gene,networks,,allowing,flexible,incorporation,network,information,studies,HumanNet,performs,well,ranking,disease-linked,gene,sets,minimal,literature-dependent,biases,observe,incorporating,model,organisms',protein-protein,interactions,markedly,improve,disease,gene,predictions,,suggesting,many,disease,gene,associations,now,captured,directly,human-derived,datasets,improved,interactive,user,interface,disease,network,analysis,,expect,HumanNet,will,useful,resource,network,medicine.<br>Prioritizing,candidate,disease,genes,network-based,boosting,genome-wide,association,data,Network,"guilt,association",,GBA,,proven,approach,identifying,novel,disease,genes,based,observation,similar,mutational,phenotypes,arise,functionally,related,genes,principle,,approach,account,even,nonadditive,genetic,interactions,,underlie,synergistic,combinations,mutations,often,linked,complex,diseases,,analyze,large-scale,,human,gene,functional,interaction,network,,dubbed,HumanNet,,show,candidate,disease,genes,can,effectively,identified,GBA,cross-validated,tests,using,label,propagation,algorithms,related,Google's,PageRank,However,,GBA,shown,work,poorly,genome-wide,association,studies,,GWAS,,,many,genes,somewhat,implicated,,known,high,certainty,,resolve,explicitly,modeling,uncertainty,associations,incorporating,uncertainty,seed,set,GBA,framework,observe,significant,boost,power,detect,validated,candidate,genes,Crohn's,disease,type,2,diabetes,comparing,predictions,results,follow-up,meta-analyses,,incorporation,network,serving,highlight,JAK-STAT,pathway,associated,adaptors,GRB2/SHC1,Crohn's,disease,BACH2,type,2,diabetes,Consideration,network,GWAS,thus,conveys,benefits,enrolling,participants,GWAS,study,generally,,demonstrate,functional,network,human,genes,provides,valuable,statistical,framework,prioritizing,candidate,disease,genes,,candidate,gene-based,GWAS-based,studies.<br>HumanNet,v3:,improved,database,human,gene,networks,disease,research,Network,medicine,proven,useful,dissecting,genetic,organization,complex,human,diseases,previously,published,HumanNet,,integrated,network,human,genes,disease,studies,Since,release,last,version,HumanNet,,many,large-scale,protein-protein,interaction,datasets,accumulated,public,depositories,Additionally,,numbers,research,papers,functional,annotations,gene-phenotype,associations,increased,significantly,Therefore,,updating,HumanNet,timely,task,improvement,network-based,research,diseases,,present,HumanNet,v3,,https://www.inetbio.org/humannet/,,covering,99.8%,human,protein,coding,genes,,constructed,means,expanded,data,improved,network,inference,algorithms,HumanNet,v3,supports,three-tier,model:,HumanNet-PI,,protein-protein,physical,interaction,network,,,HumanNet-FN,,functional,gene,network,,,HumanNet-XC,,functional,network,extended,co-citation,,Users,can,select,suitable,tier,HumanNet,study,purpose,showed,disease,gene,predictions,,HumanNet,v3,outperforms,previous,HumanNet,version,integrated,human,gene,networks,Furthermore,,demonstrated,HumanNet,provides,feasible,approach,selecting,host,genes,likely,associated,COVID-19.,HumanNet,v2:,human,gene,networks,disease,research,Human,gene,networks,proven,useful,many,aspects,disease,research,,numerous,network-based,strategies,developed,generating,hypotheses,gene-disease-drug,associations,ability,predict,organize,genes,relevant,specific,disease,proven,especially,important,previously,developed,human,functional,gene,network,,HumanNet,,integrating,diverse,types,omics,data,using,Bayesian,statistics,framework,demonstrated,ability,retrieve,disease,genes,,present,HumanNet,v2,,http://www.inetbio.org/humannet,,,database,human,gene,networks,,updated,incorporating,new,data,types,,extending,data,sources,improving,network,inference,algorithms,HumanNet,now,comprises,hierarchy,human,gene,networks,,allowing,flexible,incorporation,network,information,studies,HumanNet,performs,well,ranking,disease-linked,gene,sets,minimal,literature-dependent,biases,observe,incorporating,model,organisms',protein-protein,interactions,markedly,improve,disease,gene,predictions,,suggesting,many,disease,gene,associations,now,captured,directly,human-derived,datasets,improved,interactive,user,interface,disease,network,analysis,,expect,HumanNet,will,useful,resource,network,medicine.<br>Prioritizing,candidate,disease,genes,network-based,boosting,genome-wide,association,data,Network,"guilt,association",,GBA,,proven,approach,identifying,novel,disease,genes,based,observation,similar,mutational,phenotypes,arise,functionally,related,genes,principle,,approach,account,even,nonadditive,genetic,interactions,,underlie,synergistic,combinations,mutations,often,linked,complex,diseases,,analyze,large-scale,,human,gene,functional,interaction,network,,dubbed,HumanNet,,show,candidate,disease,genes,can,effectively,identified,GBA,cross-validated,tests,using,label,propagation,algorithms,related,Google's,PageRank,However,,GBA,shown,work,poorly,genome-wide,association,studies,,GWAS,,,many,genes,somewhat,implicated,,known,high,certainty,,resolve,explicitly,modeling,uncertainty,associations,incorporating,uncertainty,seed,set,GBA,framework,observe,significant,boost,power,detect,validated,candidate,genes,Crohn's,disease,type,2,diabetes,comparing,predictions,results,follow-up,meta-analyses,,incorporation,network,serving,highlight,JAK-STAT,pathway,associated,adaptors,GRB2/SHC1,Crohn's,disease,BACH2,type,2,diabetes,Consideration,network,GWAS,thus,conveys,benefits,enrolling,participants,GWAS,study,generally,,demonstrate,functional,network,human,genes,provides,valuable,statistical,framework,prioritizing,candidate,disease,genes,,candidate,gene-based,GWAS-based,studies.<br>HumanNet,v3:,improved,database,human,gene,networks,disease,research,Network,medicine,proven,useful,dissecting,genetic,organization,complex,human,diseases,previously,published,HumanNet,,integrated,network,human,genes,disease,studies,Since,release,last,version,HumanNet,,many,large-scale,protein-protein,interaction,datasets,accumulated,public,depositories,Additionally,,numbers,research,papers,functional,annotations,gene-phenotype,associations,increased,significantly,Therefore,,updating,HumanNet,timely,task,improvement,network-based,research,diseases,,present,HumanNet,v3,,https://www.inetbio.org/humannet/,,covering,99.8%,human,protein,coding,genes,,constructed,means,expanded,data,improved,network,inference,algorithms,HumanNet,v3,supports,three-tier,model:,HumanNet-PI,,protein-protein,physical,interaction,network,,,HumanNet-FN,,functional,gene,network,,,HumanNet-XC,,functional,network,extended,co-citation,,Users,can,select,suitable,tier,HumanNet,study,purpose,showed,disease,gene,predictions,,HumanNet,v3,outperforms,previous,HumanNet,version,integrated,human,gene,networks,Furthermore,,demonstrated,HumanNet,provides,feasible,approach,selecting,host,genes,likely,associated,COVID-19.