DASHR,DASHR,DASHR,DASHR,DASHR,DASHR,DASHR,DASHR,DASHR,DASHR,DASHR,2.0:,integrated,database,human,small,non-coding,RNA,genes,mature,products,MOTIVATION:,Small,non-coding,RNAs,,sncRNAs,,<100,nts,,highly,abundant,RNAs,regulate,diverse,often,tissue-specific,cellular,processes,associating,transcription,factor,complexes,binding,mRNAs,thousands,sncRNA,genes,exist,human,genome,,single,resource,provides,searchable,,unified,annotation,,expression,processing,information,full,sncRNA,transcripts,mature,RNA,products,derived,larger,RNAs.
RESULTS:,goal,establish,complete,catalog,annotation,,expression,,processing,,conservation,,tissue-specificity,biological,features,human,sncRNA,genes,mature,products,derived,major,RNA,classes,DASHR,,Database,small,human,non-coding,RNAs,,v2.0,database,first,integrates,human,sncRNA,gene,mature,products,profiles,obtained,multiple,RNA-seq,protocols,Altogether,,185,tissues/cell,types,sncRNA,annotations,>800,curated,experiments,ENCODE,GEO/SRA,across,multiple,RNA-seq,protocols,GRCh38/hg38,GRCh37/hg19,assemblies,integrated,DASHR,Moreover,,DASHR,first,contain,known,novel,,previously,un-annotated,sncRNA,loci,identified,unsupervised,segmentation,,13,times,loci,1,678,800,total,,Additionally,,DASHR,v2.0,adds,>3,200,000,annotations,non-small,RNA,genes,genomic,features,,long-noncoding,RNAs,,mRNAs,,promoters,,repeats,,Furthermore,,DASHR,v2.0,introduces,enhanced,user,interface,,interactive,experiment-by-locus,table,view,,sncRNA,locus,sorting,filtering,biological,features,annotation,expression,information,directly,downloadable,accessible,UCSC,genome,browser,tracks.
AVAILABILITY,AND,IMPLEMENTATION:,DASHR,v2.0,freely,available,https://lisanwanglab.org/DASHRv2.
SUPPLEMENTARY,INFORMATION:,Supplementary,data,available,Bioinformatics,online.
DASHR:,database,small,human,noncoding,RNAs,Small,non-coding,RNAs,,sncRNAs,,highly,abundant,RNAs,,typically,<100,nucleotides,long,,act,key,regulators,diverse,cellular,processes,Although,thousands,sncRNA,genes,known,exist,human,genome,,single,database,provides,searchable,,unified,annotation,,expression,information,full,sncRNA,transcripts,mature,RNA,products,derived,larger,RNAs,,present,Database,small,human,noncoding,RNAs,,DASHR,,DASHR,contains,comprehensive,information,date,human,sncRNA,genes,mature,sncRNA,products,DASHR,provides,simple,user,interface,researchers,view,sequence,secondary,structure,,compare,expression,levels,,evidence,specific,processing,across,sncRNA,genes,mature,sncRNA,products,various,human,tissues,DASHR,annotation,expression,data,covers,major,classes,sncRNAs,including,microRNAs,,miRNAs,,,Piwi-interacting,,piRNAs,,,small,nuclear,,nucleolar,,cytoplasmic,,sn-,,sno-,,scRNAs,,respectively,,,transfer,,tRNAs,,,ribosomal,RNAs,,rRNAs,,Currently,,DASHR,,v1.0,,integrates,187,smRNA,high-throughput,sequencing,,smRNA-seq,,datasets,2.5,billion,reads,annotation,data,multiple,public,sources,DASHR,contains,annotations,∼,48,000,human,sncRNA,genes,mature,sncRNA,products,,82%,expressed,one,curated,tissues,DASHR,available,http://lisanwanglab.org/DASHR.,DASHR,2.0:,integrated,database,human,small,non-coding,RNA,genes,mature,products,MOTIVATION:,Small,non-coding,RNAs,,sncRNAs,,<100,nts,,highly,abundant,RNAs,regulate,diverse,often,tissue-specific,cellular,processes,associating,transcription,factor,complexes,binding,mRNAs,thousands,sncRNA,genes,exist,human,genome,,single,resource,provides,searchable,,unified,annotation,,expression,processing,information,full,sncRNA,transcripts,mature,RNA,products,derived,larger,RNAs.
RESULTS:,goal,establish,complete,catalog,annotation,,expression,,processing,,conservation,,tissue-specificity,biological,features,human,sncRNA,genes,mature,products,derived,major,RNA,classes,DASHR,,Database,small,human,non-coding,RNAs,,v2.0,database,first,integrates,human,sncRNA,gene,mature,products,profiles,obtained,multiple,RNA-seq,protocols,Altogether,,185,tissues/cell,types,sncRNA,annotations,>800,curated,experiments,ENCODE,GEO/SRA,across,multiple,RNA-seq,protocols,GRCh38/hg38,GRCh37/hg19,assemblies,integrated,DASHR,Moreover,,DASHR,first,contain,known,novel,,previously,un-annotated,sncRNA,loci,identified,unsupervised,segmentation,,13,times,loci,1,678,800,total,,Additionally,,DASHR,v2.0,adds,>3,200,000,annotations,non-small,RNA,genes,genomic,features,,long-noncoding,RNAs,,mRNAs,,promoters,,repeats,,Furthermore,,DASHR,v2.0,introduces,enhanced,user,interface,,interactive,experiment-by-locus,table,view,,sncRNA,locus,sorting,filtering,biological,features,annotation,expression,information,directly,downloadable,accessible,UCSC,genome,browser,tracks.
AVAILABILITY,AND,IMPLEMENTATION:,DASHR,v2.0,freely,available,https://lisanwanglab.org/DASHRv2.
SUPPLEMENTARY,INFORMATION:,Supplementary,data,available,Bioinformatics,online.
DASHR:,database,small,human,noncoding,RNAs,Small,non-coding,RNAs,,sncRNAs,,highly,abundant,RNAs,,typically,<100,nucleotides,long,,act,key,regulators,diverse,cellular,processes,Although,thousands,sncRNA,genes,known,exist,human,genome,,single,database,provides,searchable,,unified,annotation,,expression,information,full,sncRNA,transcripts,mature,RNA,products,derived,larger,RNAs,,present,Database,small,human,noncoding,RNAs,,DASHR,,DASHR,contains,comprehensive,information,date,human,sncRNA,genes,mature,sncRNA,products,DASHR,provides,simple,user,interface,researchers,view,sequence,secondary,structure,,compare,expression,levels,,evidence,specific,processing,across,sncRNA,genes,mature,sncRNA,products,various,human,tissues,DASHR,annotation,expression,data,covers,major,classes,sncRNAs,including,microRNAs,,miRNAs,,,Piwi-interacting,,piRNAs,,,small,nuclear,,nucleolar,,cytoplasmic,,sn-,,sno-,,scRNAs,,respectively,,,transfer,,tRNAs,,,ribosomal,RNAs,,rRNAs,,Currently,,DASHR,,v1.0,,integrates,187,smRNA,high-throughput,sequencing,,smRNA-seq,,datasets,2.5,billion,reads,annotation,data,multiple,public,sources,DASHR,contains,annotations,∼,48,000,human,sncRNA,genes,mature,sncRNA,products,,82%,expressed,one,curated,tissues,DASHR,available,http://lisanwanglab.org/DASHR.