MeQTL EPIC Database,MeQTL EPIC Database,MeQTL EPIC Database,MeQTL EPIC Database,MeQTL EPIC Database,MeQTL EPIC Database,MeQTL EPIC Database,MeQTL EPIC Database,MeQTL EPIC Database,MeQTL EPIC Database,Genetic,impacts,DNA,methylation,help,elucidate,regulatory,genomic,processes,BACKGROUND:,Pinpointing,genetic,impacts,DNA,methylation,can,improve,understanding,pathways,underlie,gene,regulation,disease,risk.<br>RESULTS:,report,heritability,methylation,quantitative,trait,locus,,meQTL,,analysis,724,499,CpGs,profiled,Illumina,Infinium,MethylationEPIC,array,2358,blood,samples,three,UK,cohorts,Methylation,levels,34.2%,CpGs,affected,SNPs,,98%,effects,cis-acting,within,1,Mbp,tested,CpG,results,consistent,meQTL,analyses,based,former,Illumina,Infinium,HumanMethylation450,array,SNPs,CpGs,meQTLs,overrepresented,enhancers,,improved,coverage,platform,compared,previous,approaches,Co-localisation,analyses,across,genetic,effects,DNA,methylation,56,human,traits,identify,1520,co-localisations,across,1325,unique,CpGs,34,phenotypes,,including,disease-relevant,genes,,USP1,DOCK7,,total,cholesterol,levels,,,ICOSLG,,inflammatory,bowel,disease,,Enrichment,analysis,meQTLs,integration,expression,QTLs,give,insights,mechanisms,underlying,cis-meQTLs,,e.g,disruption,transcription,factor,binding,sites,CTCF,SMC3,,trans-meQTLs,,e.g,regulating,expression,ACD,SENP7,can,modulate,DNA,methylation,distal,sites,.<br>CONCLUSIONS:,findings,improve,characterisation,mechanisms,underlying,DNA,methylation,variability,informative,prioritisation,GWAS,variants,functional,follow-ups,MeQTL,EPIC,Database,viewer,available,online,https://epicmeqtl.kcl.ac.uk,.<br>,Genetic,impacts,DNA,methylation,help,elucidate,regulatory,genomic,processes,BACKGROUND:,Pinpointing,genetic,impacts,DNA,methylation,can,improve,understanding,pathways,underlie,gene,regulation,disease,risk.<br>RESULTS:,report,heritability,methylation,quantitative,trait,locus,,meQTL,,analysis,724,499,CpGs,profiled,Illumina,Infinium,MethylationEPIC,array,2358,blood,samples,three,UK,cohorts,Methylation,levels,34.2%,CpGs,affected,SNPs,,98%,effects,cis-acting,within,1,Mbp,tested,CpG,results,consistent,meQTL,analyses,based,former,Illumina,Infinium,HumanMethylation450,array,SNPs,CpGs,meQTLs,overrepresented,enhancers,,improved,coverage,platform,compared,previous,approaches,Co-localisation,analyses,across,genetic,effects,DNA,methylation,56,human,traits,identify,1520,co-localisations,across,1325,unique,CpGs,34,phenotypes,,including,disease-relevant,genes,,USP1,DOCK7,,total,cholesterol,levels,,,ICOSLG,,inflammatory,bowel,disease,,Enrichment,analysis,meQTLs,integration,expression,QTLs,give,insights,mechanisms,underlying,cis-meQTLs,,e.g,disruption,transcription,factor,binding,sites,CTCF,SMC3,,trans-meQTLs,,e.g,regulating,expression,ACD,SENP7,can,modulate,DNA,methylation,distal,sites,.<br>CONCLUSIONS:,findings,improve,characterisation,mechanisms,underlying,DNA,methylation,variability,informative,prioritisation,GWAS,variants,functional,follow-ups,MeQTL,EPIC,Database,viewer,available,online,https://epicmeqtl.kcl.ac.uk,.<br>