Database Commons
Database Commons

a catalog of worldwide biological databases

Database Profile

General information

URL: http://bicresources.jcbose.ac.in
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Description: PSCRIdb is a manually curated database of regulatory interactions including protein-protein, protein-DNA, gene-gene, and miRNA-mRNA interactions in mouse and human pluripotent stem cells including embryonic stem cells and embryonic carcinoma cells. At present, 22 different mouse and human pluripotent stem-cell-line-specific regulatory interactions are compiled in the database. Detailed information of the four types of interaction data are presented in tabular format and graphical network view in Cytoscape layout.
Year founded: 2020
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Country/Region: India

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Contact information

University/Institution: Bose Institute
Address: Division of Bioinformatics, Bose Institute, Kolkata, India.
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Country/Region: India
Contact name (PI/Team): SUDIPTO SAHA
Contact email (PI/Helpdesk): ssaha4@gmail.com

Publications

32345779
PSCRIdb: A database of regulatory interactions and networks of pluripotent stem cell lines. [PMID: 32345779]
Krishnendu Banerjee, Tanmoy Jana, Zhumur Ghosh, Sudipto Saha

Pluripotency in stem cells is regulated by a complex network between the transcription factors, signaling molecules, mRNAs, and epigenetic regulators like non-coding RNAs. Different pluripotent stem cell (PSC) lines were isolated and characterized to study the regulatory network topology to understand the mechanism that control developmental potential of pluripotent cells. PSCRIdb is a manually curated database of regulatory interactions including protein-protein, protein-DNA, gene-gene, and miRNA-mRNA interactions in mouse and human pluripotent stem cells including embryonic stem cells and embryonic carcinoma cells. At present, 22 different mouse and human pluripotent stem-cell-line-specific regulatory interactions are compiled in the database. Detailed information of the four types of interaction data are presented in tabular format and graphical network view in Cytoscape layout. The database is available at http://bicresources.jcbose.ac.in/ ssaha4/pscridb. The database contains 3037 entries of experimentally validated molecular interactions that can be useful for systematic study of pluripotency integrating multi-omics data. In summary, the database can be a useful resource for identification of regulatory networks present in different pluripotent stem cell lines.

J. Biosci.. 2020:45() | 0 Citations (from Europe PMC, 2022-08-13)

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Record metadata

Created on: 2020-11-07
Curated by:
Lin Liu [2022-08-03]
Lin Liu [2021-03-23]
Chang Liu [2020-11-24]
Yitong Pan [2020-11-07]