Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

URL: https://ccsm.uth.edu/ADeditome/
Full name: ADeditome
Description: ADeditome, the annotation database of A-to-I RNA editing in Alzheimer's disease (AD), aiming to provide a resource and reference for functional annotation of A-to-I RNA editing in AD to identify therapeutically targetable genes in an individual.
Year founded: 2021
Last update: 2021
Version:
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Country/Region: United States
Data type:
RNA
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Contact information

University/Institution: Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston
Address:
City: Houston
Province/State: Texas
Country/Region: United States
Contact name (PI/Team): Xiaobo Zhou
Contact email (PI/Helpdesk): Xiaobo.Zhou@uth.tmc.edu

Publications

33401309
ADeditome provides the genomic landscape of A-to-I RNA editing in Alzheimer's disease. [PMID: 33401309]
Sijia Wu, Mengyuan Yang, Pora Kim, Xiaobo Zhou

A-to-I RNA editing, contributing to nearly 90% of all editing events in human, has been reported to involve in the pathogenesis of Alzheimer's disease (AD) due to its roles in brain development and immune regulation, such as the deficient editing of GluA2 Q/R related to cell death and memory loss. Currently, there are urgent needs for the systematic annotations of A-to-I RNA editing events in AD. Here, we built ADeditome, the annotation database of A-to-I RNA editing in AD available at https://ccsm.uth.edu/ADeditome, aiming to provide a resource and reference for functional annotation of A-to-I RNA editing in AD to identify therapeutically targetable genes in an individual. We detected 1676 363 editing sites in 1524 samples across nine brain regions from ROSMAP, MayoRNAseq and MSBB. For these editing events, we performed multiple functional annotations including identification of specific and disease stage associated editing events and the influence of editing events on gene expression, protein recoding, alternative splicing and miRNA regulation for all the genes, especially for AD-related genes in order to explore the pathology of AD. Combing all the analysis results, we found 108 010 and 26 168 editing events which may promote or inhibit AD progression, respectively. We also found 5582 brain region-specific editing events with potentially dual roles in AD across different brain regions. ADeditome will be a unique resource for AD and drug research communities to identify therapeutically targetable editing events. Significance: ADeditome is the first comprehensive resource of the functional genomics of individual A-to-I RNA editing events in AD, which will be useful for many researchers in the fields of AD pathology, precision medicine, and therapeutic researches.

Brief Bioinform. 2021:() | 0 Citations (from Europe PMC, 2021-09-18)

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Record metadata

Created on: 2021-09-07
Curated by:
Dong Zou [2021-09-14]
Tianyi Xu [2021-09-07]