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Database Profile

General information

Full name: non-B cell derived immunoglobulin vatiable-region database
Description: NBIGV is a database dedicated to organizing and characterizing non-B cell derived immunoglobulins
Year founded: 2021
Last update:
Real time : Checking...
Country/Region: China

Contact information

University/Institution: Department of Immunology, School of Basic Medical Sciences, Peking University
Address: Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
City: Beijing
Country/Region: China
Contact name (PI/Team): Xiaoyan Qiu
Contact email (PI/Helpdesk):


NBIGV-DB: A dedicated database of non-B cell derived immunoglobulin variable region. [PMID: 33359127]
Chi Zhang, Lin Xiao, Yan Huang, Li Zhang, Dongyang Jiang, Wenwei Shao, Jie Zheng, Fanlei Hu, Ming Chu, Jing Huang, Xiaoting Gong, Yuan Zhou, Xiaoyan Qiu

Immunoglobulins (Ig) are important immune molecules that possess highly diverse variable region sequences enabling antigen recognition. According to classical immune theory, B lymphocytes have been considered the only source of Ig production (B-Igs). However, accumulating evidence have suggested that Igs are also produced by many non-B cells (non-B Igs), including epithelial cells, neurons, germ cells, as well as myeloid cells of hemopoietic system. Besides acting as bona fide antibodies, Non-B Igs have alternative cellular functions, such as promotion of cell survival, adhesion and migration. More importantly, Unlike the unlimited sequence diversity of B-Igs, the non-B Igs exhibit conserved V(D)J patterns across the same lineages. To support the analysis and comparison of variable region sequences from Igs, produced by B and non-B cells, we established a database (NBIGV) constituted by a non-B Ig variable region repertoire, which includes 727,989 VDJ and VκJκ recombination sequences of non-B Igs sequenced from mouse samples. Upon database search, users can view, browse and investigate the variable region sequences of non-B Igs according to respective mice strains and tissues as well as Ig classes. Moreover, users can easily download selected sequences and/or compare sequences of interest with known non-B Ig sequences present in the database using NCBI-BLAST algorithms. Additionally, our database integrates a submission page and supplementary sample information. The NBIGV database may serve as a valuable resource for sequence analyses of Non-B Igs. NBIGV database is freely available at

Gene. 2021:772() | 1 Citations (from Europe PMC, 2022-07-02)


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3983/5381 (25.999%)
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Record metadata

Created on: 2022-04-19
Curated by:
Lin Liu [2022-06-23]
Qianpeng Li [2022-05-11]
Sicheng Luo [2022-04-19]