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Database Commons

a catalog of worldwide biological databases

Database Profile

General information

Full name: Factor X Gene (F10) Variant Database
Description: FX is a plasma glycoprotein that plays a key role in the coagulation cascade. The website is an interactive FX variant database based on earlier web sites for the factor-XI and -IX coagulation proteins.
Year founded: 2021
Last update: 2021-04
Version: 1.0
Real time : Checking...
Country/Region: United Kingdom

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Contact information

University/Institution: University of London
Address: Senate House, Malet Street, London, Greater London WC1E 7HU, United Kingdom
City: London
Country/Region: United Kingdom
Contact name (PI/Team): s.perkins
Contact email (PI/Helpdesk):


Analysis of 180 Genetic Variants in a New Interactive FX Variant Database Reveals Novel Insights into FX Deficiency. [PMID: 35059555]
Victoria A Harris, Weining Lin, Stephen J Perkins

Coagulation factor X (FX), often termed as Stuart-Prower factor, is a plasma glycoprotein composed of the γ-carboxyglutamic acid (GLA) domain, two epidermal growth factor domains (EGF-1 and EGF-2), and the serine protease (SP) domain. FX plays a pivotal role in the coagulation cascade, activating thrombin to promote platelet plug formation and prevent excess blood loss. Genetic variants in FX disrupt coagulation and lead to FX or Stuart-Prower factor deficiency. To better understand the relationship between FX deficiency and disease severity, an interactive FX variant database has been set up at , based on earlier web sites for the factor-XI and -IX coagulation proteins. To date (April 2021), we report 427 case reports on FX deficiency corresponding to 180 distinct genetic variants. Of these, 149 are point variants (of which 128 are missense), 22 are deletions, 3 are insertions, and 6 are polymorphisms. FX variants are phenotypically classified as being type I or II. Type-I variants involve the simultaneous reduction of FX coagulant activity (FX:C) and FX antigen levels (FX:Ag), whereas type-II variants involve a reduction in FX:C with normal FX:Ag plasma levels. Both types of variants were distributed throughout the FXa protein structure. Analyses based on residue surface accessibilities showed the most damaging variants to occur at residues with low accessibilities. The interactive FX web database provides a novel easy-to-use resource for clinicians and scientists to improve the understanding of FX deficiency. Guidelines are provided for clinicians who wish to use the database for diagnostic purposes.

TH Open. 2021:5(4) | 0 Citations (from Europe PMC, 2023-03-18)



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Created on: 2022-04-25
Curated by:
Lina Ma [2022-06-01]
sun yongqing [2022-05-14]