| GO:0005524 |
ATP binding |
molecular_function |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| GO:0005515 |
protein binding |
molecular_function |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| GO:0008017 |
microtubule binding |
molecular_function |
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
| GO:0003777 |
microtubule motor activity |
molecular_function |
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). |
| GO:0007018 |
microtubule-based movement |
biological_process |
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. |
| GO:0005737 |
cytoplasm |
cellular_component |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| GO:0000166 |
nucleotide binding |
molecular_function |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| GO:0005739 |
mitochondrion |
cellular_component |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| GO:0005856 |
cytoskeleton |
cellular_component |
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| GO:1904115 |
axon cytoplasm |
cellular_component |
Any cytoplasm that is part of a axon. |
| GO:0006915 |
apoptotic process |
biological_process |
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| GO:0030054 |
cell junction |
cellular_component |
A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| GO:0031410 |
cytoplasmic vesicle |
cellular_component |
A vesicle found in the cytoplasm of a cell. |
| GO:0005874 |
microtubule |
cellular_component |
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| GO:0030659 |
cytoplasmic vesicle membrane |
cellular_component |
The lipid bilayer surrounding a cytoplasmic vesicle. |
| GO:0016887 |
ATPase activity |
molecular_function |
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. |
| GO:0045202 |
synapse |
cellular_component |
The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
| GO:0016192 |
vesicle-mediated transport |
biological_process |
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
| GO:0043005 |
neuron projection |
cellular_component |
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| GO:0005875 |
microtubule associated complex |
cellular_component |
Any multimeric complex connected to a microtubule. |
| GO:0030705 |
cytoskeleton-dependent intracellular transport |
biological_process |
The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. |
| GO:0030424 |
axon |
cellular_component |
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| GO:0030425 |
dendrite |
cellular_component |
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| GO:0005871 |
kinesin complex |
cellular_component |
Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. |
| GO:0008089 |
anterograde axonal transport |
biological_process |
The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. |
| GO:0019894 |
kinesin binding |
molecular_function |
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. |
| GO:0008021 |
synaptic vesicle |
cellular_component |
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| GO:0008574 |
ATP-dependent microtubule motor activity, plus-end-directed |
molecular_function |
Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP. |
| GO:0007270 |
neuron-neuron synaptic transmission |
biological_process |
The process of synaptic transmission from a neuron to another neuron across a synapse. |
| GO:0007274 |
neuromuscular synaptic transmission |
biological_process |
The process of synaptic transmission from a neuron to a muscle, across a synapse. |
| GO:0019900 |
kinase binding |
molecular_function |
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| GO:0097110 |
scaffold protein binding |
molecular_function |
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. |
| GO:1990939 |
ATP-dependent microtubule motor activity |
molecular_function |
Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP. |
| GO:0010628 |
positive regulation of gene expression |
biological_process |
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
| GO:0010970 |
transport along microtubule |
biological_process |
The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. |
| GO:0032418 |
lysosome localization |
biological_process |
Any process in which a lysosome is transported to, and/or maintained in, a specific location. |
| GO:0047497 |
mitochondrion transport along microtubule |
biological_process |
The directed movement of a mitochondrion along a microtubule, mediated by motor proteins. |
| GO:1904647 |
response to rotenone |
biological_process |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus. |
| GO:1990048 |
anterograde neuronal dense core vesicle transport |
biological_process |
The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse. |
| GO:1990049 |
retrograde neuronal dense core vesicle transport |
biological_process |
The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body. |
| GO:1990090 |
cellular response to nerve growth factor stimulus |
biological_process |
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. |
| GO:1990778 |
protein localization to cell periphery |
biological_process |
A process in which a protein is transported to, or maintained in, the cell periphery. |
| GO:0016020 |
membrane |
cellular_component |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| GO:0007088 |
regulation of mitotic nuclear division |
biological_process |
Any process that modulates the frequency, rate or extent of mitosis. |
| GO:0003774 |
motor activity |
molecular_function |
Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. |
