| GO:0005525 |
GTP binding |
molecular_function |
Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
| GO:0005794 |
Golgi apparatus |
cellular_component |
A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| GO:0003924 |
GTPase activity |
molecular_function |
Catalysis of the reaction: GTP + H2O = GDP + phosphate. |
| GO:0016192 |
vesicle-mediated transport |
biological_process |
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
| GO:0005802 |
trans-Golgi network |
cellular_component |
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
| GO:0031982 |
vesicle |
cellular_component |
Any small, fluid-filled, spherical organelle enclosed by membrane. |
| GO:0005737 |
cytoplasm |
cellular_component |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| GO:0016020 |
membrane |
cellular_component |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| GO:0015031 |
protein transport |
biological_process |
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| GO:0005829 |
cytosol |
cellular_component |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| GO:0000166 |
nucleotide binding |
molecular_function |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| GO:0005856 |
cytoskeleton |
cellular_component |
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| GO:0005886 |
plasma membrane |
cellular_component |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| GO:0005515 |
protein binding |
molecular_function |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| GO:0048471 |
perinuclear region of cytoplasm |
cellular_component |
Cytoplasm situated near, or occurring around, the nucleus. |
| GO:0030154 |
cell differentiation |
biological_process |
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| GO:0006886 |
intracellular protein transport |
biological_process |
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| GO:0070062 |
extracellular exosome |
cellular_component |
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| GO:0032482 |
Rab protein signal transduction |
biological_process |
A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| GO:0012505 |
endomembrane system |
cellular_component |
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| GO:0042147 |
retrograde transport, endosome to Golgi |
biological_process |
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
| GO:0005773 |
vacuole |
cellular_component |
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
| GO:0042470 |
melanosome |
cellular_component |
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| GO:0017137 |
Rab GTPase binding |
molecular_function |
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. |
| GO:0007005 |
mitochondrion organization |
biological_process |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| GO:0005739 |
mitochondrion |
cellular_component |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| GO:0072657 |
protein localization to membrane |
biological_process |
A process in which a protein is transported to, or maintained in, a specific location in a membrane. |
| GO:0019003 |
GDP binding |
molecular_function |
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. |
| GO:0019894 |
kinesin binding |
molecular_function |
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. |
| GO:0070840 |
dynein complex binding |
molecular_function |
Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. |
| GO:0001921 |
positive regulation of receptor recycling |
biological_process |
Any process that activates or increases the frequency, rate or extent of receptor recycling. |
| GO:0007030 |
Golgi organization |
biological_process |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. |
| GO:0007416 |
synapse assembly |
biological_process |
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). |
| GO:0009617 |
response to bacterium |
biological_process |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| GO:0010977 |
negative regulation of neuron projection development |
biological_process |
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| GO:0032438 |
melanosome organization |
biological_process |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. |
| GO:0039694 |
viral RNA genome replication |
biological_process |
The replication of a viral RNA genome. |
| GO:0042110 |
T cell activation |
biological_process |
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
| GO:0050862 |
positive regulation of T cell receptor signaling pathway |
biological_process |
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
| GO:0090316 |
positive regulation of intracellular protein transport |
biological_process |
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. |
| GO:1901214 |
regulation of neuron death |
biological_process |
Any process that modulates the frequency, rate or extent of neuron death. |
| GO:1901998 |
toxin transport |
biological_process |
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| GO:1903441 |
protein localization to ciliary membrane |
biological_process |
A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. |
| GO:1905279 |
regulation of retrograde transport, endosome to Golgi |
biological_process |
Any process that modulates the frequency, rate or extent of retrograde transport, endosome to Golgi. |
| GO:0005769 |
early endosome |
cellular_component |
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| GO:0005801 |
cis-Golgi network |
cellular_component |
The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. |
| GO:0020003 |
symbiont-containing vacuole |
cellular_component |
Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont. |
| GO:0055037 |
recycling endosome |
cellular_component |
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
| GO:0097708 |
intracellular vesicle |
cellular_component |
Any vesicle that is part of the intracellular region. |
