ENSG00000181104 - Gene Expression Nebulas

Accession ID: ENSG00000181104

来源: Ensembl

基因Symbol: F2R

Related IDs:

Entrez ID: 2149

HGNC ID: HGNC:23515

Refseq ID: NM_001311313; NM_001992; NP_001298242; NP_001983;

Location: 5:76716126-76735770(+)

描述信息: coagulation factor II thrombin receptor

基因Biotype: protein_coding

Band: p11.2

GC含量: 43.94

HK/TS: NA

表型: NA

GeneCard:

Accession	转录本Symbol	染色体	起始位点	终止位点	链信息	Transcript Biotype

GO Term ID	GO Term Name	GO Domain	GO Term定义
GO:0007186	G protein-coupled receptor signaling pathway	biological_process	A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
GO:0016021	integral component of membrane	cellular_component	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0004930	G protein-coupled receptor activity	molecular_function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0007596	blood coagulation	biological_process	The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
GO:0015057	thrombin-activated receptor activity	molecular_function	A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
GO:0070493	thrombin-activated receptor signaling pathway	biological_process	The series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
GO:0008285	negative regulation of cell population proliferation	biological_process	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	biological_process	Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
GO:0030335	positive regulation of cell migration	biological_process	Any process that activates or increases the frequency, rate or extent of cell migration.
GO:0005623	obsolete cell	cellular_component	OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0045893	positive regulation of transcription, DNA-templated	biological_process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
GO:0016020	membrane	cellular_component	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0005886	plasma membrane	cellular_component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0005515	protein binding	molecular_function	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0007165	signal transduction	biological_process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0045202	synapse	cellular_component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
GO:0006954	inflammatory response	biological_process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
GO:0009986	cell surface	cellular_component	The external part of the cell wall and/or plasma membrane.
GO:0045211	postsynaptic membrane	cellular_component	A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
GO:0001965	G-protein alpha-subunit binding	molecular_function	Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
GO:0031681	G-protein beta-subunit binding	molecular_function	Interacting selectively and non-covalently with a G-protein beta subunit.
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological_process	Any process that increases the concentration of calcium ions in the cytosol.
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	biological_process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
GO:0030194	positive regulation of blood coagulation	biological_process	Any process that activates or increases the frequency, rate or extent of blood coagulation.
GO:0032496	response to lipopolysaccharide	biological_process	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
GO:0032651	regulation of interleukin-1 beta production	biological_process	Any process that modulates the frequency, rate, or extent of interleukin-1 beta production.
GO:0035025	positive regulation of Rho protein signal transduction	biological_process	Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
GO:0045907	positive regulation of vasoconstriction	biological_process	Any process that activates or increases the frequency, rate or extent of vasoconstriction.
GO:0048873	homeostasis of number of cells within a tissue	biological_process	Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological_process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	biological_process	Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse.
GO:1900134	negative regulation of renin secretion into blood stream	biological_process	Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream.
GO:0005576	extracellular region	cellular_component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO:0005769	early endosome	cellular_component	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
GO:0005887	integral component of plasma membrane	cellular_component	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0043547	positive regulation of GTPase activity	biological_process	Any process that activates or increases the activity of a GTPase.
GO:0007599	hemostasis	biological_process	The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
GO:0051928	positive regulation of calcium ion transport	biological_process	Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:2000778	positive regulation of interleukin-6 secretion	biological_process	Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.
GO:0005770	late endosome	cellular_component	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological_process	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
GO:0008284	positive regulation of cell population proliferation	biological_process	Any process that activates or increases the rate or extent of cell proliferation.
GO:0043524	negative regulation of neuron apoptotic process	biological_process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
GO:2000484	positive regulation of interleukin-8 secretion	biological_process	Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion.
GO:0005794	Golgi apparatus	cellular_component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
GO:0030168	platelet activation	biological_process	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-act	biological_process	Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
GO:0009653	anatomical structure morphogenesis	biological_process	The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
GO:0005102	signaling receptor binding	molecular_function	Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	biological_process	The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
GO:0031594	neuromuscular junction	cellular_component	The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	biological_process	Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
GO:0000186	activation of MAPKK activity	biological_process	The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
GO:0005901	caveola	cellular_component	A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
GO:0051209	release of sequestered calcium ion into cytosol	biological_process	The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
GO:0060155	platelet dense granule organization	biological_process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins.
GO:0009611	response to wounding	biological_process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
GO:0032967	positive regulation of collagen biosynthetic process	biological_process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	biological_process	The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
GO:0043410	positive regulation of MAPK cascade	biological_process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
GO:0045217	cell-cell junction maintenance	biological_process	The maintenance of junctions between cells.
GO:0051930	regulation of sensory perception of pain	biological_process	Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
GO:0002248	connective tissue replacement involved in inflammatory response wound healing	biological_process	The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response.
GO:0003105	negative regulation of glomerular filtration	biological_process	Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.
GO:0007529	establishment of synaptic specificity at neuromuscular junction	biological_process	The biological process in which a synapse between a motor neuron and a muscle is initially formed.
GO:0030193	regulation of blood coagulation	biological_process	Any process that modulates the frequency, rate or extent of blood coagulation.
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological_process	Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
GO:0045987	positive regulation of smooth muscle contraction	biological_process	Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.
GO:0031094	platelet dense tubular network	cellular_component	A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin.

DOID	Parent DOID	疾病名称	同义词	疾病定义
DOID:11722	DOID:450	myotonic dystrophy type 1	Dystrophia myotonica;Steinert disease;myotonic dystrophy of Steinert;congenital myotonic dystrophy	A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_material_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region.

GEN中的表达水平

GTEx中的表达水平

平均TPM	中位数TPM	最大值TPM	最小值TPM	CV	τ-Value	Tissue Breadth	GTEx	REDIportal
14.13	8.55	78.74	0.15	1.21	0.84	53

使用JBrowse可视化显示测序覆盖水平、编辑水平以及编辑位点

数据集ID	上调/下调	log FC	P-value	Adj-value	平均表达量	分组比较	疾病	组织	细胞类型	细胞系	GEN样本名称

Gene Expression Nebulas

Homo sapiens: ENSG00000181104

GEN中的表达水平

GTEx中的表达水平

使用JBrowse可视化显示测序覆盖水平、编辑水平以及编辑位点