GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
biological_process |
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. |
GO:0004713 |
protein tyrosine kinase activity |
molecular_function |
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. |
GO:0006468 |
protein phosphorylation |
biological_process |
The process of introducing a phosphate group on to a protein. |
GO:0004672 |
protein kinase activity |
molecular_function |
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
GO:0005524 |
ATP binding |
molecular_function |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
GO:0016021 |
integral component of membrane |
cellular_component |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
GO:0016020 |
membrane |
cellular_component |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
GO:0000166 |
nucleotide binding |
molecular_function |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
molecular_function |
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
GO:0016301 |
kinase activity |
molecular_function |
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
GO:0016740 |
transferase activity |
molecular_function |
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
GO:0016310 |
phosphorylation |
biological_process |
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
biological_process |
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
GO:0008284 |
positive regulation of cell population proliferation |
biological_process |
Any process that activates or increases the rate or extent of cell proliferation. |
GO:0030154 |
cell differentiation |
biological_process |
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
GO:0005887 |
integral component of plasma membrane |
cellular_component |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
GO:0043235 |
receptor complex |
cellular_component |
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
GO:0007275 |
multicellular organism development |
biological_process |
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). |
GO:0043066 |
negative regulation of apoptotic process |
biological_process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
GO:0033674 |
positive regulation of kinase activity |
biological_process |
Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
GO:0050679 |
positive regulation of epithelial cell proliferation |
biological_process |
Any process that activates or increases the rate or extent of epithelial cell proliferation. |
GO:0003682 |
chromatin binding |
molecular_function |
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
GO:0004888 |
transmembrane signaling receptor activity |
molecular_function |
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
GO:0005006 |
epidermal growth factor-activated receptor activity |
molecular_function |
Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
GO:0019899 |
enzyme binding |
molecular_function |
Interacting selectively and non-covalently with any enzyme. |
GO:0019900 |
kinase binding |
molecular_function |
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
GO:0019903 |
protein phosphatase binding |
molecular_function |
Interacting selectively and non-covalently with any protein phosphatase. |
GO:0030235 |
nitric-oxide synthase regulator activity |
molecular_function |
Modulates the activity of nitric oxide synthase. |
GO:0031625 |
ubiquitin protein ligase binding |
molecular_function |
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. |
GO:0042802 |
identical protein binding |
molecular_function |
Interacting selectively and non-covalently with an identical protein or proteins. |
GO:0048408 |
epidermal growth factor binding |
molecular_function |
Interacting selectively and non-covalently with epidermal growth factor. |
GO:0051015 |
actin filament binding |
molecular_function |
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
GO:0001934 |
positive regulation of protein phosphorylation |
biological_process |
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
GO:0007165 |
signal transduction |
biological_process |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
GO:0007166 |
cell surface receptor signaling pathway |
biological_process |
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
biological_process |
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
GO:0010750 |
positive regulation of nitric oxide mediated signal transduction |
biological_process |
Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO). |
GO:0014066 |
regulation of phosphatidylinositol 3-kinase signaling |
biological_process |
Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. |
GO:0030307 |
positive regulation of cell growth |
biological_process |
Any process that activates or increases the frequency, rate, extent or direction of cell growth. |
GO:0030335 |
positive regulation of cell migration |
biological_process |
Any process that activates or increases the frequency, rate or extent of cell migration. |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
biological_process |
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
GO:0034614 |
cellular response to reactive oxygen species |
biological_process |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. |
GO:0038083 |
peptidyl-tyrosine autophosphorylation |
biological_process |
The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. |
GO:0042177 |
negative regulation of protein catabolic process |
biological_process |
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
GO:0042327 |
positive regulation of phosphorylation |
biological_process |
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. |
GO:0043406 |
positive regulation of MAP kinase activity |
biological_process |
Any process that activates or increases the frequency, rate or extent of MAP kinase activity. |
GO:0045737 |
positive regulation of cyclin-dependent protein serine/threonine kinase activity |
biological_process |
Any process that activates or increases the frequency, rate or extent of CDK activity. |
GO:0045739 |
positive regulation of DNA repair |
biological_process |
Any process that activates or increases the frequency, rate or extent of DNA repair. |
GO:0045740 |
positive regulation of DNA replication |
biological_process |
Any process that activates or increases the frequency, rate or extent of DNA replication. |
GO:0045893 |
positive regulation of transcription, DNA-templated |
biological_process |
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
biological_process |
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
GO:0046328 |
regulation of JNK cascade |
biological_process |
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
GO:0046777 |
protein autophosphorylation |
biological_process |
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
GO:0050730 |
regulation of peptidyl-tyrosine phosphorylation |
biological_process |
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
GO:0050999 |
regulation of nitric-oxide synthase activity |
biological_process |
Any process that modulates the activity of the enzyme nitric-oxide synthase. |
GO:0051897 |
positive regulation of protein kinase B signaling |
biological_process |
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
GO:0070141 |
response to UV-A |
biological_process |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. |
GO:0070372 |
regulation of ERK1 and ERK2 cascade |
biological_process |
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
biological_process |
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
GO:0071276 |
cellular response to cadmium ion |
biological_process |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. |
GO:0071392 |
cellular response to estradiol stimulus |
biological_process |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
GO:0090263 |
positive regulation of canonical Wnt signaling pathway |
biological_process |
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
GO:0098609 |
cell-cell adhesion |
biological_process |
The attachment of one cell to another cell via adhesion molecules. |
GO:1900020 |
positive regulation of protein kinase C activity |
biological_process |
Any process that activates or increases the frequency, rate or extent of protein kinase C activity. |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
biological_process |
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
biological_process |
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
biological_process |
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. |
GO:1903800 |
positive regulation of production of miRNAs involved in gene silencing by miRNA |
biological_process |
Any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA. |
GO:1905208 |
negative regulation of cardiocyte differentiation |
biological_process |
Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. |
GO:0009925 |
basal plasma membrane |
cellular_component |
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
GO:0005634 |
nucleus |
cellular_component |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
GO:0005737 |
cytoplasm |
cellular_component |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
GO:0005768 |
endosome |
cellular_component |
A vacuole to which materials ingested by endocytosis are delivered. |
GO:0005886 |
plasma membrane |
cellular_component |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
GO:0009986 |
cell surface |
cellular_component |
The external part of the cell wall and/or plasma membrane. |
GO:0010008 |
endosome membrane |
cellular_component |
The lipid bilayer surrounding an endosome. |
GO:0016323 |
basolateral plasma membrane |
cellular_component |
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
GO:0030054 |
cell junction |
cellular_component |
A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
GO:0031901 |
early endosome membrane |
cellular_component |
The lipid bilayer surrounding an early endosome. |
GO:0032587 |
ruffle membrane |
cellular_component |
The portion of the plasma membrane surrounding a ruffle. |
GO:0032991 |
protein-containing complex |
cellular_component |
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
GO:0045121 |
membrane raft |
cellular_component |
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
GO:0048471 |
perinuclear region of cytoplasm |
cellular_component |
Cytoplasm situated near, or occurring around, the nucleus. |
GO:0097489 |
multivesicular body, internal vesicle lumen |
cellular_component |
The volume enclosed by the membrane of the multivesicular body internal vesicle. |
GO:0097708 |
intracellular vesicle |
cellular_component |
Any vesicle that is part of the intracellular region. |