Mesocricetus auratus - Gene Expression Nebulas

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Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Reiterer M, Rajan M, Gómez-Banoy N, Lau JD, Gomez-Escobar LG, Ma L, Gilani A, Alvarez-Mulett S, Sholle ET, Chandar V, Bram Y, Hoffman K, Bhardwaj P, Piloco P, Rubio-Navarro A, Uhl S, Carrau L, Houhgton S, Redmond D, Shukla AP, Goyal P, Brown KA, tenOever BR, Alonso LC, Schwartz RE, Schenck EJ, Safford MM, Lo JC. Cell Metab. 2021-12-01; 33 (12) PMID: 34879241 DOI: 10.1016/j.cmet.2021.10.014
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions. Bakowski MA, Beutler N, Wolff KC, Kirkpatrick MG, Chen E, Nguyen TH, Riva L, Shaabani N, Parren M, Ricketts J, Gupta AK, Pan K, Kuo P, Fuller M, Garcia E, Teijaro JR, Yang L, Sahoo D, Chi V, Huang E, Vargas N, Roberts AJ, Das S, Ghosh P, Woods AK, Joseph SB, Hull MV, Schultz PG, Burton DR, Chatterjee AK, McNamara CW, Rogers TF. Nat Commun. 2021-06-03; 12 (1) PMID: 34083527 DOI: 10.1038/s41467-021-23328-0
Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters. Yuan S, Yin X, Meng X, Chan J, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan C, Poon V, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Sze KH, Zhang J, Chu H, Kok KH, To K, Jin DY, Sun R, Chanda S, Yuen KY. Res Sq. 2020-10-07; PMID: 33052331 DOI: 10.21203/rs.3.rs-86169/v1
Attenuated activation of pulmonary immune cells in mRNA-1273-vaccinated hamsters after SARS-CoV-2 infection. Meyer M, Wang Y, Edwards D, Smith GR, Rubenstein AB, Ramanathan P, Mire CE, Pietzsch C, Chen X, Ge Y, Cheng WS, Henry C, Woods A, Ma L, Stewart-Jones GB, Bock KW, Minai M, Nagata BM, Periasamy S, Shi PY, Graham BS, Moore IN, Ramos I, Troyanskaya OG, Zaslavsky E, Carfi A, Sealfon SC, Bukreyev A. J Clin Invest. 2021-10-01; 131 (20) PMID: 34449440 DOI: 10.1172/jci148036
AI-guided discovery of the invariant host response to viral pandemics. Sahoo D, Katkar GD, Khandelwal S, Behroozikhah M, Claire A, Castillo V, Tindle C, Fuller M, Taheri S, Rogers TF, Beutler N, Ramirez SI, Rawlings SA, Pretorius V, Smith DM, Burton DR, Alexander LEC, Duran J, Crotty S, Dan JM, Das S, Ghosh P. EBioMedicine. 2021-06-11; 68 PMID: 34127431 DOI: 10.1016/j.ebiom.2021.103390
An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells. Lamers MM, van der Vaart J, Knoops K, Riesebosch S, Breugem TI, Mykytyn AZ, Beumer J, Schipper D, Bezstarosti K, Koopman CD, Groen N, Ravelli RBG, Duimel HQ, Demmers JAA, Verjans GMGM, Koopmans MPG, Muraro MJ, Peters PJ, Clevers H, Haagmans BL. EMBO J. 2021-01-11; 40 (5) PMID: 33283287 DOI: 10.15252/embj.2020105912
AI-guided discovery of the invariant host response to viral pandemics. Sahoo D, Katkar GD, Khandelwal S, Behroozikhah M, Claire A, Castillo V, Tindle C, Fuller M, Taheri S, Rogers TF, Beutler N, Ramirez SI, Rawlings SA, Pretorius V, Smith DM, Burton DR, Alexander LEC, Duran J, Crotty S, Dan JM, Das S, Ghosh P. bioRxiv. 2021-04-13; PMID: 32995790 DOI: 10.1101/2020.09.21.305698
High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster. Port JR, Adney DR, Schwarz B, Schulz JE, Sturdevant DE, Smith BJ, Avanzato VA, Holbrook MG, Purushotham JN, Stromberg KA, Leighton I, Bosio CM, Shaia C, Munster VJ. Viruses. 2021-12-14; 13 (12) PMID: 34960775 DOI: 10.3390/v13122506

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2.

Reiterer M, Rajan M, Gómez-Banoy N, Lau JD, Gomez-Escobar LG, Ma L, Gilani A, Alvarez-Mulett S, Sholle ET, Chandar V, Bram Y, Hoffman K, Bhardwaj P, Piloco P, Rubio-Navarro A, Uhl S, Carrau L, Houhgton S, Redmond D, Shukla AP, Goyal P, Brown KA, tenOever BR, Alonso LC, Schwartz RE, Schenck EJ, Safford MM, Lo JC.

Cell Metab. 2021-12-01; 33 (12)

PMID: 34879241 DOI: 10.1016/j.cmet.2021.10.014

Drug repurposing screens identify chemical entities for the development of COVID-19 interventions.

Bakowski MA, Beutler N, Wolff KC, Kirkpatrick MG, Chen E, Nguyen TH, Riva L, Shaabani N, Parren M, Ricketts J, Gupta AK, Pan K, Kuo P, Fuller M, Garcia E, Teijaro JR, Yang L, Sahoo D, Chi V, Huang E, Vargas N, Roberts AJ, Das S, Ghosh P, Woods AK, Joseph SB, Hull MV, Schultz PG, Burton DR, Chatterjee AK, McNamara CW, Rogers TF.

Nat Commun. 2021-06-03; 12 (1)

PMID: 34083527 DOI: 10.1038/s41467-021-23328-0

Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters.

Yuan S, Yin X, Meng X, Chan J, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan C, Poon V, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Sze KH, Zhang J, Chu H, Kok KH, To K, Jin DY, Sun R, Chanda S, Yuen KY.

Res Sq. 2020-10-07;

PMID: 33052331 DOI: 10.21203/rs.3.rs-86169/v1

Attenuated activation of pulmonary immune cells in mRNA-1273-vaccinated hamsters after SARS-CoV-2 infection.

Meyer M, Wang Y, Edwards D, Smith GR, Rubenstein AB, Ramanathan P, Mire CE, Pietzsch C, Chen X, Ge Y, Cheng WS, Henry C, Woods A, Ma L, Stewart-Jones GB, Bock KW, Minai M, Nagata BM, Periasamy S, Shi PY, Graham BS, Moore IN, Ramos I, Troyanskaya OG, Zaslavsky E, Carfi A, Sealfon SC, Bukreyev A.

J Clin Invest. 2021-10-01; 131 (20)

PMID: 34449440 DOI: 10.1172/jci148036

AI-guided discovery of the invariant host response to viral pandemics.

Sahoo D, Katkar GD, Khandelwal S, Behroozikhah M, Claire A, Castillo V, Tindle C, Fuller M, Taheri S, Rogers TF, Beutler N, Ramirez SI, Rawlings SA, Pretorius V, Smith DM, Burton DR, Alexander LEC, Duran J, Crotty S, Dan JM, Das S, Ghosh P.

EBioMedicine. 2021-06-11; 68

PMID: 34127431 DOI: 10.1016/j.ebiom.2021.103390

An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells.

Lamers MM, van der Vaart J, Knoops K, Riesebosch S, Breugem TI, Mykytyn AZ, Beumer J, Schipper D, Bezstarosti K, Koopman CD, Groen N, Ravelli RBG, Duimel HQ, Demmers JAA, Verjans GMGM, Koopmans MPG, Muraro MJ, Peters PJ, Clevers H, Haagmans BL.

EMBO J. 2021-01-11; 40 (5)

PMID: 33283287 DOI: 10.15252/embj.2020105912

AI-guided discovery of the invariant host response to viral pandemics.

bioRxiv. 2021-04-13;

PMID: 32995790 DOI: 10.1101/2020.09.21.305698

High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster.

Port JR, Adney DR, Schwarz B, Schulz JE, Sturdevant DE, Smith BJ, Avanzato VA, Holbrook MG, Purushotham JN, Stromberg KA, Leighton I, Bosio CM, Shaia C, Munster VJ.

Viruses. 2021-12-14; 13 (12)

PMID: 34960775 DOI: 10.3390/v13122506

Gene Expression Nebulas

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