Mus musculus - Gene Expression Nebulas

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CCR2 Signaling Restricts SARS-CoV-2 Infection. Vanderheiden A, Thomas J, Soung AL, Davis-Gardner ME, Floyd K, Jin F, Cowan DA, Pellegrini K, Shi PY, Grakoui A, Klein RS, Bosinger SE, Kohlmeier JE, Menachery VD, Suthar MS. mBio. 2021-11-09; 12 (6) PMID: 34749524 DOI: 10.1128/mbio.02749-21
Scleral hypoxia is a target for myopia control. Wu H, Chen W, Zhao F, Zhou Q, Reinach PS, Deng L, Ma L, Luo S, Srinivasalu N, Pan M, Hu Y, Pei X, Sun J, Ren R, Xiong Y, Zhou Z, Zhang S, Tian G, Fang J, Zhang L, Lang J, Wu D, Zeng C, Qu J, Zhou X. Proc Natl Acad Sci U S A. 2018-07-09; 115 (30) PMID: 29987045 DOI: 10.1073/pnas.1721443115
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium. Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Negretti NM, Kapp ME, Benjamin JT, Gulleman P, Nichols DS, Braunstein LZ, Hackett A, Koval M, Guttentag SH, Blackwell TS, Webber SA, Banovich NE, Vanderbilt COVID-19 Consortium Cohort, Human Cell Atlas Biological Network, Kropski JA, Sucre JM. J Clin Invest. 2021-01-01; 131 (1) PMID: 33180746 DOI: 10.1172/jci140766
Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis. Musiu C, Caligola S, Fiore A, Lamolinara A, Frusteri C, Del Pizzo FD, De Sanctis F, Canè S, Adamo A, Hofer F, Barouni RM, Grilli A, Zilio S, Serafini P, Tacconelli E, Donadello K, Gottin L, Polati E, Girelli D, Polidoro I, Iezzi PA, Angelucci D, Capece A, Chen Y, Shi ZL, Murray PJ, Chilosi M, Amit I, Bicciato S, Iezzi M, Bronte V, Ugel S. Cell Death Differ. 2021-09-13; PMID: 34518653 DOI: 10.1038/s41418-021-00866-0
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma. Geng J, Chen L, Yuan Y, Wang K, Wang Y, Qin C, Wu G, Chen R, Zhang Z, Wei D, Du P, Zhang J, Lin P, Zhang K, Deng Y, Xu K, Liu J, Sun X, Guo T, Yang X, Wu J, Jiang J, Li L, Zhang K, Wang Z, Zhang J, Yan Q, Zhu H, Zheng Z, Miao J, Fu X, Yang F, Chen X, Tang H, Zhang Y, Shi Y, Zhu Y, Pei Z, Huo F, Liang X, Wang Y, Wang Q, Xie W, Li Y, Shi M, Bian H, Zhu P, Chen ZN. Signal Transduct Target Ther. 2021-09-25; 6 (1) PMID: 34564690 DOI: 10.1038/s41392-021-00760-8
Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Guo Q, Zhao Y, Li J, Liu J, Yang X, Guo X, Kuang M, Xia H, Zhang Z, Cao L, Luo Y, Bao L, Wang X, Wei X, Deng W, Wang N, Chen L, Chen J, Zhu H, Gao R, Qin C, Wang X, You F. Cell Host Microbe. 2020-12-26; 29 (2) PMID: 33388094 DOI: 10.1016/j.chom.2020.12.016
Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2. Sun S, Gu H, Cao L, Chen Q, Ye Q, Yang G, Li RT, Fan H, Deng YQ, Song X, Qi Y, Li M, Lan J, Feng R, Guo Y, Zhu N, Qin S, Wang L, Zhang YF, Zhou C, Zhao L, Chen Y, Shen M, Cui Y, Yang X, Wang X, Tan W, Wang H, Wang X, Qin CF. Nat Commun. 2021-09-27; 12 (1) PMID: 34580297 DOI: 10.1038/s41467-021-25903-x
Ultraconserved Enhancers Are Required for Normal Development. Dickel DE, Ypsilanti AR, Pla R, Zhu Y, Barozzi I, Mannion BJ, Khin YS, Fukuda-Yuzawa Y, Plajzer-Frick I, Pickle CS, Lee EA, Harrington AN, Pham QT, Garvin TH, Kato M, Osterwalder M, Akiyama JA, Afzal V, Rubenstein JLR, Pennacchio LA, Visel A. Cell. 2018-01-18; 172 (3) PMID: 29358049 DOI: 10.1016/j.cell.2017.12.017
SARS-CoV-2 infection in the mouse olfactory system. Ye Q, Zhou J, He Q, Li RT, Yang G, Zhang Y, Wu SJ, Chen Q, Shi JH, Zhang RR, Zhu HM, Qiu HY, Zhang T, Deng YQ, Li XF, Liu JF, Xu P, Yang X, Qin CF. Cell Discov. 2021-07-06; 7 (1) PMID: 34230457 DOI: 10.1038/s41421-021-00290-1
IL-13 is a driver of COVID-19 severity. Donlan AN, Sutherland TE, Marie C, Preissner S, Bradley BT, Carpenter RM, Sturek JM, Ma JZ, Moreau GB, Donowitz JR, Buck GA, Serrano MG, Burgess SL, Abhyankar MM, Mura C, Bourne PE, Preissner R, Young MK, Lyons GR, Loomba JJ, Ratcliffe SJ, Poulter MD, Mathers AJ, Day AJ, Mann BJ, Allen JE, Petri WA. JCI Insight. 2021-08-09; 6 (15) PMID: 34185704 DOI: 10.1172/jci.insight.150107
Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. Ryu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov M, Wang A, Dixit VD. Elife. 2021-06-21; 10 PMID: 34151773 DOI: 10.7554/elife.66522
Gene expression variability across cells and species shapes innate immunity. Hagai T, Chen X, Miragaia RJ, Rostom R, Gomes T, Kunowska N, Henriksson J, Park JE, Proserpio V, Donati G, Bossini-Castillo L, Vieira Braga FA, Naamati G, Fletcher J, Stephenson E, Vegh P, Trynka G, Kondova I, Dennis M, Haniffa M, Nourmohammad A, Lässig M, Teichmann SA. Nature. 2018-10-24; 563 (7730) PMID: 30356220 DOI: 10.1038/s41586-018-0657-2
Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model. Yang T, Poenisch M, Khanal R, Hu Q, Dai Z, Li R, Song G, Yuan Q, Yao Q, Shen X, Taubert R, Engel B, Jaeckel E, Vogel A, Falk CS, Schambach A, Gerovska D, Araúzo-Bravo MJ, Vondran FWR, Cantz T, Horscroft N, Balakrishnan A, Chevessier F, Ott M, Sharma AD. J Hepatol. 2021-08-25; 75 (6) PMID: 34453962 DOI: 10.1016/j.jhep.2021.08.011
Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2-induced systemic toxicity. Li S, Ma F, Yokota T, Garcia G, Palermo A, Wang Y, Farrell C, Wang YC, Wu R, Zhou Z, Pan C, Morselli M, Teitell MA, Ryazantsev S, Fishbein GA, Hoeve JT, Arboleda VA, Bloom J, Dillon B, Pellegrini M, Lusis AJ, Graeber TG, Arumugaswami V, Deb A. JCI Insight. 2021-01-25; 6 (2) PMID: 33284134 DOI: 10.1172/jci.insight.145027
The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory. Ndeupen S, Qin Z, Jacobsen S, Estanbouli H, Bouteau A, Igyártó BZ. bioRxiv. 2021-07-23; PMID: 33688649 DOI: 10.1101/2021.03.04.430128
Cell fixation and preservation for droplet-based single-cell transcriptomics. Alles J, Karaiskos N, Praktiknjo SD, Grosswendt S, Wahle P, Ruffault PL, Ayoub S, Schreyer L, Boltengagen A, Birchmeier C, Zinzen R, Kocks C, Rajewsky N. BMC Biol. 2017-05-19; 15 (1) PMID: 28526029 DOI: 10.1186/s12915-017-0383-5
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion. Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D'Adamo P, Kuka M, Guidotti LG, Iannacone M. Sci Immunol. 2022-01-28; 7 (67) PMID: 34812647 DOI: 10.1126/sciimmunol.abl9929
Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts. Chen W, Wang X, Wei G, Huang Y, Shi Y, Li D, Qiu S, Zhou B, Cao J, Chen M, Qin P, Jin W, Ni T. Front Genet. 2020-08-11; 11 PMID: 32849838 DOI: 10.3389/fgene.2020.00867
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Peng L, Hu Y, Mankowski MC, Ren P, Chen RE, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow RD, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S. bioRxiv. 2021-12-24; PMID: 34981065 DOI: 10.1101/2021.12.21.473733
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection. Winkler ES, Gilchuk P, Yu J, Bailey AL, Chen RE, Chong Z, Zost SJ, Jang H, Huang Y, Allen JD, Case JB, Sutton RE, Carnahan RH, Darling TL, Boon ACM, Mack M, Head RD, Ross TM, Crowe JE, Diamond MS. Cell. 2021-02-12; 184 (7) PMID: 33691139 DOI: 10.1016/j.cell.2021.02.026

CCR2 Signaling Restricts SARS-CoV-2 Infection.

Vanderheiden A, Thomas J, Soung AL, Davis-Gardner ME, Floyd K, Jin F, Cowan DA, Pellegrini K, Shi PY, Grakoui A, Klein RS, Bosinger SE, Kohlmeier JE, Menachery VD, Suthar MS.

mBio. 2021-11-09; 12 (6)

PMID: 34749524 DOI: 10.1128/mbio.02749-21

Scleral hypoxia is a target for myopia control.

Wu H, Chen W, Zhao F, Zhou Q, Reinach PS, Deng L, Ma L, Luo S, Srinivasalu N, Pan M, Hu Y, Pei X, Sun J, Ren R, Xiong Y, Zhou Z, Zhang S, Tian G, Fang J, Zhang L, Lang J, Wu D, Zeng C, Qu J, Zhou X.

Proc Natl Acad Sci U S A. 2018-07-09; 115 (30)

PMID: 29987045 DOI: 10.1073/pnas.1721443115

Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium.

Schuler BA, Habermann AC, Plosa EJ, Taylor CJ, Jetter C, Negretti NM, Kapp ME, Benjamin JT, Gulleman P, Nichols DS, Braunstein LZ, Hackett A, Koval M, Guttentag SH, Blackwell TS, Webber SA, Banovich NE, Vanderbilt COVID-19 Consortium Cohort, Human Cell Atlas Biological Network, Kropski JA, Sucre JM.

J Clin Invest. 2021-01-01; 131 (1)

PMID: 33180746 DOI: 10.1172/jci140766

Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis.

Musiu C, Caligola S, Fiore A, Lamolinara A, Frusteri C, Del Pizzo FD, De Sanctis F, Canè S, Adamo A, Hofer F, Barouni RM, Grilli A, Zilio S, Serafini P, Tacconelli E, Donadello K, Gottin L, Polati E, Girelli D, Polidoro I, Iezzi PA, Angelucci D, Capece A, Chen Y, Shi ZL, Murray PJ, Chilosi M, Amit I, Bicciato S, Iezzi M, Bronte V, Ugel S.

Cell Death Differ. 2021-09-13;

PMID: 34518653 DOI: 10.1038/s41418-021-00866-0

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma.

Geng J, Chen L, Yuan Y, Wang K, Wang Y, Qin C, Wu G, Chen R, Zhang Z, Wei D, Du P, Zhang J, Lin P, Zhang K, Deng Y, Xu K, Liu J, Sun X, Guo T, Yang X, Wu J, Jiang J, Li L, Zhang K, Wang Z, Zhang J, Yan Q, Zhu H, Zheng Z, Miao J, Fu X, Yang F, Chen X, Tang H, Zhang Y, Shi Y, Zhu Y, Pei Z, Huo F, Liang X, Wang Y, Wang Q, Xie W, Li Y, Shi M, Bian H, Zhu P, Chen ZN.

Signal Transduct Target Ther. 2021-09-25; 6 (1)

PMID: 34564690 DOI: 10.1038/s41392-021-00760-8

Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.

Guo Q, Zhao Y, Li J, Liu J, Yang X, Guo X, Kuang M, Xia H, Zhang Z, Cao L, Luo Y, Bao L, Wang X, Wei X, Deng W, Wang N, Chen L, Chen J, Zhu H, Gao R, Qin C, Wang X, You F.

Cell Host Microbe. 2020-12-26; 29 (2)

PMID: 33388094 DOI: 10.1016/j.chom.2020.12.016

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2.

Sun S, Gu H, Cao L, Chen Q, Ye Q, Yang G, Li RT, Fan H, Deng YQ, Song X, Qi Y, Li M, Lan J, Feng R, Guo Y, Zhu N, Qin S, Wang L, Zhang YF, Zhou C, Zhao L, Chen Y, Shen M, Cui Y, Yang X, Wang X, Tan W, Wang H, Wang X, Qin CF.

Nat Commun. 2021-09-27; 12 (1)

PMID: 34580297 DOI: 10.1038/s41467-021-25903-x

Ultraconserved Enhancers Are Required for Normal Development.

Dickel DE, Ypsilanti AR, Pla R, Zhu Y, Barozzi I, Mannion BJ, Khin YS, Fukuda-Yuzawa Y, Plajzer-Frick I, Pickle CS, Lee EA, Harrington AN, Pham QT, Garvin TH, Kato M, Osterwalder M, Akiyama JA, Afzal V, Rubenstein JLR, Pennacchio LA, Visel A.

Cell. 2018-01-18; 172 (3)

PMID: 29358049 DOI: 10.1016/j.cell.2017.12.017

SARS-CoV-2 infection in the mouse olfactory system.

Ye Q, Zhou J, He Q, Li RT, Yang G, Zhang Y, Wu SJ, Chen Q, Shi JH, Zhang RR, Zhu HM, Qiu HY, Zhang T, Deng YQ, Li XF, Liu JF, Xu P, Yang X, Qin CF.

Cell Discov. 2021-07-06; 7 (1)

PMID: 34230457 DOI: 10.1038/s41421-021-00290-1

IL-13 is a driver of COVID-19 severity.

Donlan AN, Sutherland TE, Marie C, Preissner S, Bradley BT, Carpenter RM, Sturek JM, Ma JZ, Moreau GB, Donowitz JR, Buck GA, Serrano MG, Burgess SL, Abhyankar MM, Mura C, Bourne PE, Preissner R, Young MK, Lyons GR, Loomba JJ, Ratcliffe SJ, Poulter MD, Mathers AJ, Day AJ, Mann BJ, Allen JE, Petri WA.

JCI Insight. 2021-08-09; 6 (15)

PMID: 34185704 DOI: 10.1172/jci.insight.150107

Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice.

Ryu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov M, Wang A, Dixit VD.

Elife. 2021-06-21; 10

PMID: 34151773 DOI: 10.7554/elife.66522

Gene expression variability across cells and species shapes innate immunity.

Hagai T, Chen X, Miragaia RJ, Rostom R, Gomes T, Kunowska N, Henriksson J, Park JE, Proserpio V, Donati G, Bossini-Castillo L, Vieira Braga FA, Naamati G, Fletcher J, Stephenson E, Vegh P, Trynka G, Kondova I, Dennis M, Haniffa M, Nourmohammad A, Lässig M, Teichmann SA.

Nature. 2018-10-24; 563 (7730)

PMID: 30356220 DOI: 10.1038/s41586-018-0657-2

Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model.

Yang T, Poenisch M, Khanal R, Hu Q, Dai Z, Li R, Song G, Yuan Q, Yao Q, Shen X, Taubert R, Engel B, Jaeckel E, Vogel A, Falk CS, Schambach A, Gerovska D, Araúzo-Bravo MJ, Vondran FWR, Cantz T, Horscroft N, Balakrishnan A, Chevessier F, Ott M, Sharma AD.

J Hepatol. 2021-08-25; 75 (6)

PMID: 34453962 DOI: 10.1016/j.jhep.2021.08.011

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2-induced systemic toxicity.

Li S, Ma F, Yokota T, Garcia G, Palermo A, Wang Y, Farrell C, Wang YC, Wu R, Zhou Z, Pan C, Morselli M, Teitell MA, Ryazantsev S, Fishbein GA, Hoeve JT, Arboleda VA, Bloom J, Dillon B, Pellegrini M, Lusis AJ, Graeber TG, Arumugaswami V, Deb A.

JCI Insight. 2021-01-25; 6 (2)

PMID: 33284134 DOI: 10.1172/jci.insight.145027

The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory.

Ndeupen S, Qin Z, Jacobsen S, Estanbouli H, Bouteau A, Igyártó BZ.

bioRxiv. 2021-07-23;

PMID: 33688649 DOI: 10.1101/2021.03.04.430128

Cell fixation and preservation for droplet-based single-cell transcriptomics.

Alles J, Karaiskos N, Praktiknjo SD, Grosswendt S, Wahle P, Ruffault PL, Ayoub S, Schreyer L, Boltengagen A, Birchmeier C, Zinzen R, Kocks C, Rajewsky N.

BMC Biol. 2017-05-19; 15 (1)

PMID: 28526029 DOI: 10.1186/s12915-017-0383-5

Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion.

Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D'Adamo P, Kuka M, Guidotti LG, Iannacone M.

Sci Immunol. 2022-01-28; 7 (67)

PMID: 34812647 DOI: 10.1126/sciimmunol.abl9929

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts.

Chen W, Wang X, Wei G, Huang Y, Shi Y, Li D, Qiu S, Zhou B, Cao J, Chen M, Qin P, Jin W, Ni T.

Front Genet. 2020-08-11; 11

PMID: 32849838 DOI: 10.3389/fgene.2020.00867

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617.

Peng L, Hu Y, Mankowski MC, Ren P, Chen RE, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow RD, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S.

bioRxiv. 2021-12-24;

PMID: 34981065 DOI: 10.1101/2021.12.21.473733

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection.

Winkler ES, Gilchuk P, Yu J, Bailey AL, Chen RE, Chong Z, Zost SJ, Jang H, Huang Y, Allen JD, Case JB, Sutton RE, Carnahan RH, Darling TL, Boon ACM, Mack M, Head RD, Ross TM, Crowe JE, Diamond MS.

Cell. 2021-02-12; 184 (7)

PMID: 33691139 DOI: 10.1016/j.cell.2021.02.026

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