Whole Genome Sequencing in Esophageal Squamous Cell Carcinoma
Release date:
2020-07-23
Description:
In this project, we performed deep WGS in microneedle-punctured formalin fixed paraffin embedded tumor tissues and matched adjacent noncancerous specimens on a large set of ESCC patients with clinical follow up data. Herein, we classify ESCC into three main subtypes based on clinically relevant genomic alterations and implicate the association of these subtypes with outcomes of patients. Our genomic study uncovers an extensive landscape of driver genetic alterations across coding and noncoding regions, and defines their potential molecular pathology in ESCC.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
Organization: National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
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HRA000021.xlsx