Single-cell RNA-seq deciphers leukocyte subpopulations in human decidual and peripheral blood from normal and RSA pregnancies
Release date:
2021-01-06
Description:
Maternal fetal immune tolerance is a biological event that plays a key role in pregnancy. In particular, the mechanism by which the maternal immune system does not exclude the semi-identical antigen of the fetus has not been fully answered so far. The most serious result of the maternal fetal immune tolerance balance is the recurrent spontaneous abortion (RSA). The fetus is rejected by the mother in the early pregnancy and cannot continue to develop in the uterus. Based on these scientific questions, we used single-cell sequencing technology to analyze nearly 65,000 leukocytes in the decidua of normal and RSA. A total of 22 immune cell subsets were found. We clearly recognize that the immune system has dynamic changes compared with normal pregnancy under pathological conditions, which is likely to occur in RSA. The important factors, we expect our results to provide a new basis for RSA's immune diagnosis and treatment strategy.
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Organization: Institute of Zoology, Chinese Academy of Sciences
Submission date: 2020-07-20
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HRA000237.xlsx