Single cell analysis reveals onset of multiple progression associated transcriptomic remodellings in prostate cancer
Prostate cancer shows remarkable clinical heterogeneity, which strongly manifests at the genomic level. By contrast, the transcriptomic heterogeneity of prostate tumors is poorly understood. We profiled the transcriptomes of 36,424 single-cells from 13 prostate tumors and identified lineage specific epithelial cells underlying disease aggressiveness. The tumor microenvironment showed activation of multiple progression-associated transcriptomic programs.
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