Single-cell transcriptome analysis reveals cell lineage specification in temporal-spatial patterns in human cortical development
Release date:
2020-12-04
Description:
Neurogenesis processes differ in different areas of the cortex in many species, including humans. Here, we performed single-cell transcriptome profiling of the four cortical lobes and pons during human embryonic and fetal development. We identified distinct subtypes of neural progenitor cells (NPCs) and their molecular signatures, including a group of previously unidentified transient NPCs. We specified the neurogenesis path and molecular regulations of the human deep-layer, upper-layer, and mature neurons. Additionally, we verified region-specific characteristics of neurons in the cortex, including their distinct electro- physiological features.
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