Single-cell RNA sequencing reveals the heterogeneity of infiltrating immune cell profiling in hepatic cystic Echinococcosis microenvironment
Release date:
2021-01-05
Description:
Cystic Echinococcosis (CE), caused by infection with larval stage of tapeworm Echinococcus granulus sensu lato (E. granulosus s.l.), represents a near-cosmopolitan zoonotic disease. Various infiltrating immune cells gather around the lesion and produce a lesion microenvironment, but the unique composition and cellular heterogeneity in hepatic CE lesion microenvironment are incompletely understood. Here, 88020 immune cells isolated from peripheral blood (PB), adjacent normal (AN) liver tissue and peri-lesion liver (PL) tissue from four CE patients were profiled using single-cell RNA sequencing (scRNA-seq).
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HRA000543.xlsx