Silicosis is a fatal occupational lung disease that has no effective cures clinically to date. Current studies on the mechanism of silicosis were mainly restricted to rodent models or human cell lines, which may not reflect the true states in human lungs. Thus, a comprehensive profiling of the molecular changes in human silicosis lungs is urgently needed. Here, RNA sequencing (RNA-seq) was conducted for the lung tissues of 10 silicosis patients and 7 non-diseased lung donors. Comparative transcriptome analysis was performed between the two groups to detect differential genes and pathways.
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HRA000560.xlsx