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HRA000625
   HRA000625.xlsx
Title:
T cell Tolerance Induction of HSCT
Release date:
2021-02-03
Description:
Here, we characterized the gene expression profile in tolerant T cells which was induced in healthy donors by granulocyte colony-stimulating factor, a stem cell mobilizer extensively used in HSCT. We identified suppressor of cytokine signaling 1 (SOCS1) as an essential immune checkpoint for T cell tolerance in the mouse models and primary T cells in the HSCT context. Further spatial multiomics analysis characterized the distinct three-dimensional genome architecture and the gene regulatory network in tolerant T cells. We found STAT3 competes with CTCF and mediates the formation of a new chromatin loop between the SOCS1 promoter and upstream super enhancers during the induction of T cell tolerance. This study identifies SOCS1 as a key immune checkpoint and potential immune target for improving outcome of patients with HSCT.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA004411
Study type:
human 3D genome
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000395
DAC name:
T cell Tolerance Induction
Contact person:
li Ruifeng
Email:
lirf@pku.edu.cn
Description:
Spatial Multiomics Analysis Identifies SOCS1 as a Key Immune Checkpoint in T cell Tolerance Induction of HSCT
Individuals & samples
Files
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Submitter:   li cheng / cheng_li@pku.edu.cn
Organization:   Peking University
Submission date:   2021-02-01
Requests:   1