An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis
Release date:
2021-06-23
Description:
Here, we explore the functions of an alternatively spliced human CTCF isoform (CTCF-s). Functionally, we find that CTCF-s competes with the genome binding of canonical CTCF and binds a similar DNA sequence. CTCF-s binding disrupts CTCF/cohesin binding, alters CTCF-mediated chromatin looping and promotes the activation of IFI6 that leads to apoptosis. This effect is caused by an abnormal long-range interaction at the IFI6 enhancer and promoter.
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Submitter: Yao Hongjie / yao_hongjie@gzlab.ac.cn
Organization: Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences
Submission date: 2021-06-18
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HRA000960.xlsx