NGDC - GSA for Human

HRA001232

HRA001232.xlsx

Title:

Single-cell transcriptomic profiling of small-cell lung cancer reveals intimate interactions between tumor cells and tumor microenvironment

Release date:

2022-11-23

Description:

Small-cell lung cancer (SCLC) is the most aggressive and lethal subtype of lung cancer for which better understandings of its biology are urgently needed. Single-cell sequencing technologies provide an opportunity to profile individual cells within the tumor microenvironment (TME) and investigate their roles in tumorigenesis processes. Here, we performed high-precision single-cell transcriptomic analysis of ~5,000 individual cells from primary tumors and matched adjacent normal lung tissues (NATs) from 11 SCLC patients, including one patient with primary and relapsed tumors. By comparing to NATs, our study revealed an immune suppressive landscape of human SCLC. Malignant cells of SCLC tumors exhibited the diversity of states mainly regarding to the cell cycle, immune and hypoxia properties. Our data also revealed intra-tumor heterogeneity of key transcriptomic factors of SCLC at single cell resolution, and uncovered related genes expression patterns and functions.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA006026

Study type:

Disease Study

Disease name:

recurrent small cell lung cancer

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC000073

DAC name:

BIOPIC_TangLab

Contact person:

Tang Fuchou

Email:

tangfuchou@pku.edu.cn

Description:

Laboratory of Stem Cells and Epigenetics

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