Chromatin Architecture Dynamics of Porcine Adiposes Provide Comparative Resources for Human Obesity
Release date:
2022-10-10
Description:
Obesity can be considered a worldwide epidemic that has become a major threat to the quality of human life at modern society. Understanding the molecular mechanisms that underlie obesity related phenotypes can help to improve treatment options and drug development. Here, we revealed their evolutionary similarity in regulatory circuitry in determine the obesity phenotype, and identified sets of species-specific genes harboring non-conserved element which may play a crucial role in species characteristics in AT biology, for example, the lack of brown AT in pigs. This large cohort scale data we presented here shall serve as a valuable resource for future searching and functional validation of regulatory elements for obesity prediction and prevention, and promoting further development of pig as a model for human obesity.
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HRA002514.xlsx