NTRK fusion in a large real-world population and the clinical utility of circulating DNA genotyping in guiding treatment with TRK inhibitors
Release date:
2022-08-24
Description:
Although TRK inhibitors have been approved for treating locally advanced or metastatic cancer patients with NTRK fusion, the prevalence, and genomic features of NTRK1/2/3 fusion in Chinese cancer patients have not been well elucidated. This study investigated the genomic context of NTRK fusion tumors using NGS in the largest Chinese real-world cohort to date. The present study also explored the utility of circulating tumor DNA in guiding the therapy of TRK inhibitors.
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HRA002685.xlsx