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HRA002855
   HRA002855.xlsx
Title:
Proteogenomic Characterization of MiT Family Translocation Renal Cell Carcinoma
Release date:
2022-10-14
Description:
Comprehensive proteogenomic analysis of microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) tumors and normal adjacent tissues is performed to elucidate the molecular landscape of this disease. Defective DNA repair plays an important role in tRCC carcinogenesis and progression. Metabolic processes are markedly dysregulated at both the mRNA and protein levels. Proteomic and phosphoproteome data identify the mTOR signaling pathway as a potential therapeutic target. Moreover, molecular subtyping and immune infiltration analysis characterize the inter-tumoral heterogeneity of tRCC. Multi-omic integration revealed the dysregulation of cellular processes affected by genomic alterations, including oxidative phosphorylation, autophagy, transcription factor activity, and proteasome function. This study represents a comprehensive proteogenomic analysis of tRCC, providing valuable insights into its biological mechanisms, disease diagnosis, and prognostication.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA011180
Study type:
Disease Study
Disease name:
renal carcinoma
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC001642
DAC name:
DAC of Renal Cell Carcinoma
Contact person:
Ding Chen
Email:
chend@fudan.edu.cn
Description:
DAC of Renal Cell Carcinoma
Individuals & samples
Files
Request Data
Submitter:   Ding Chen / chend@fudan.edu.cn
Organization:   Fudan University
Submission date:   2022-08-16
Requests:   3