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HRA002894
   HRA002894.xlsx
Title:
WNT/NOTCH Pathway Is Essential for the Maintenance and Expansion of Human MGE Progenitors
Release date:
2022-08-29
Description:
Medial ganglionic eminence (MGE)-like cells yielded from human pluripotent stem cells (hPSCs) hold great potentials for cell therapies of related neurological disorders. In this study, we find that ablation of CTNNB1 in MGE cells led to precocious cell-cycle exit and advanced neuronal differentiation. Activation of WNT signaling through genetic or chemical approach was sufficient to maintain MGE cells in an expandable manner with authentic neuronal differentiation potencies through activation of endogenous NOTCH signaling. Our findings reveal that WNT/NOTCH signaling cascade is a key player in governing the maintenance versus terminal differentiation of MGE progenitors in humans.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA011156
Study type:
Cell line related study
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000514
DAC name:
zhangxiao qing
Contact person:
zhang xiaoqing
Email:
xqzhang@tongji.edu.cn
Description:
Further information and requests for resources should be directed to and will be fulfilled by Prof. Xiaoqing Zhang.
Individuals & samples
Files
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Submitter:   zhang xiaoqing / xqzhang@tongji.edu.cn
Organization:   Tongji University
Submission date:   2022-08-12
Requests:   -